Citation :
Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., Engelborghs, S., Fladby, T., van der Flier, W. M., Frisoni, G. B., Fröhlich, L., Gill, K. D., Grimmer, T., Hort, J., Itoh, Y., Iwatsubo, T., Klimkowicz-Mrowiec, A., Landau, S. M., Lee, D. Y., Lleó, A., … Jansen, W. J. (2025). Associations of lifestyle factors with amyloid pathology in persons without dementia. Journal of Alzheimer’s Disease, 108(3), 1043–1059. https://doi.org/10.1177/13872877251379083
Full text : Here
Julie E Oomens, Stephanie JB Vos, Nancy N Maserejian, Mercè Boada, Mira Didic, Sebastiaan Engelborghs, Tormod Fladby, Wiesje M van der Flier, Giovanni B Frisoni, Lutz Fröhlich, Kiran Dip Gill, Timo Grimmer, Jakub Hort, Yoshiaki Itoh, Takeshi Iwatsubo, Aleksandra Klimkowicz-Mrowiec, Susan M Landau, Dong Young Lee, Alberto Lleó, Pablo Martinez-Lage, Alexandre de Mendonça, Philipp T Meyer, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Julius Popp, Lorena Rami, Eric M Reiman, Juha O Rinne, Karen M Rodrigue, Pascual Sánchez-Juan, Isabel Santana, Nikolaos Scarmeas, Philip Scheltens, Ingmar Skoog, Reisa A Sperling, Yaakov Stern, Sylvia Villeneuve, Gunhild Waldemar, Jens Wiltfang, Henrik Zetterberg, Daniel Alcolea, Ricardo F Allegri, Daniele Altomare, Randall J Bateman, Simone Baiardi, Ines Baldeiras, Kaj Blennow, Anouk den Braber, Mark A van Buchem, Min Soo Byun, Jiří Cerman, Kewei Chen, Elena Chipi, Gregory S Day, Alexander Drzezga, Laura L Ekblad, Stefan Förster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric Guedj, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jiménez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bjørn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marquié, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, Eloy Rodríguez-Rodriguez, Agustín Ruiz, Eckart Rüther, Jayant Sakhardande, Per Selnes, Dina Silva, Hilkka Soininen, Luiza Spiru, Akitoshi Takeda, Charlotte E Teunissen, Betty M Tijms, Lisa Vermunt, Åsa K Wallin, Wietse Wiels, Mary Yannakoulia, Dahyun Yi, Anna Zettergren, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer’s Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) research group, Rik Ossenkoppele, Frans RJ Verhey, Pieter Jelle Visser, and Willemijn J Jansen
published in Journal of Alzheimer’s Disease, November 2025.
ABSTRACT :
Background The association between lifestyle factors and Alzheimer’s disease (AD) pathophysiology remains incompletely understood.
Objective The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.
Methods For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.
Results We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66–0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73–0.99, p = 0.029; OR = 0.62, 95%CI 0.45–0.86, p = 0.004).
Conclusions In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.