{"id":3484,"date":"2026-06-22T16:47:01","date_gmt":"2026-06-22T20:47:01","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3484"},"modified":"2026-06-22T16:47:01","modified_gmt":"2026-06-22T20:47:01","slug":"oral-body-temperature-and-cerebrospinal-fluid-ptau181-in-older-adults-at-increased-risk-of-alzheimers-disease-pillet-et-al-2026","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2026\/06\/22\/oral-body-temperature-and-cerebrospinal-fluid-ptau181-in-older-adults-at-increased-risk-of-alzheimers-disease-pillet-et-al-2026\/","title":{"rendered":"Oral body temperature and cerebrospinal fluid pTau181 in older adults at increased risk of Alzheimer\u2019s disease (Pillet et al., 2026)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3220\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg\" width=\"576\" height=\"768\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg 576w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg 225w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg 9w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Pillet, P., Tremblay-Mercier, J., Picard, C., Rosa-Neto, P., Villeneuve, S., Poirier, J., Calon, F., &amp; PREVENT-AD Research Group. (2026). Oral body temperature and cerebrospinal fluid ptau181 in older adults at increased risk of alzheimer\u2019s disease. <em>Neurobiology of Aging<\/em>, <em>167<\/em>, 25\u201328. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.06.003<br><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.06.003\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"span-style-color-var-ast-global-color-0-class-stk-highlight-a-href-https-doi-org-10-1016-j-neurobiolaging-2026-06-003-oral-body-temperature-and-cerebrospinal-fluid-p-tau-181-in-older-adults-at-increased-risk-of-alzheimers-disease-a-span\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\"><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.06.003\">Oral body temperature and cerebrospinal fluid pTau181 in older adults at increased risk of Alzheimer\u2019s disease<\/a><\/span><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Paul Pillet, Jennifer Tremblay-Mercier, Cynthia Picard, Pedro Rosa-Neto, Sylvia Villeneuve, Judes Poirier, Fr\u00e9d\u00e9ric Calon, for the PREVENT-AD Research Group<\/strong><br>published in <em>Neurobiology of Aging<\/em>, November 2026. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Preclinical studies consistently associate body temperature with tau phosphorylation in the brain. This study examined the relationship between body temperature taken at lumbar puncture (LP) and CSF pTau181 levels in 142 cognitively healthy PREVENT-AD participants (\u226555 years, 39 men, 103 women) at high AD risk due to family history. CSF was collected via LP at baseline\/follow-up with prior oral temperature measurement. Levels of pTau181, total tau, and amyloid-\u03b2 peptide 42 (A\u03b2<sub>42<\/sub>) were quantified, and Spearman correlations were performed to assess their relationship with body temperature, age and sex. No significant correlation was observed between body temperature and pTau181 levels, nor with pTau181\/total tau or pTau181\/A\u03b2<sub>42<\/sub>\u00a0ratios. However, age correlated positively with pTau181 levels (r\u202f=\u202f0.21, p\u202f&lt;\u202f0.0001) and with the pTau181\/A\u03b2<sub>42<\/sub>\u00a0ratio (r\u202f=\u202f0.17, p\u202f&lt;\u202f0.001), particularly in women (r\u202f=\u202f0.23, p\u202f&lt;\u202f0.0001). These findings suggest that, under standard clinical conditions and within a narrow range of temperatures, routine oral body temperature measured at the time of LP is unlikely to represent a source of pre-analytical variability for CSF pTau181 measurements in at-risk AD individuals.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Pillet, P., Tremblay-Mercier, J., Picard, C., Rosa-Neto, P., Villeneuve, S., Poirier, J., Calon, F., &amp; PREVENT-AD Research Group. (2026). Oral body temperature and cerebrospinal fluid ptau181 in older adults at increased risk of alzheimer\u2019s disease. Neurobiology of Aging, 167, 25\u201328. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.06.003 Full text : Here Oral body temperature and cerebrospinal fluid pTau181 in [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":3220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[24,9],"tags":[15],"class_list":["post-3484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-24","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg",225,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Pillet, P., Tremblay-Mercier, J., Picard, C., Rosa-Neto, P., Villeneuve, S., Poirier, J., Calon, F., &amp; PREVENT-AD Research Group. (2026). Oral body temperature and cerebrospinal fluid ptau181 in older adults at increased risk of alzheimer\u2019s disease. Neurobiology of Aging, 167, 25\u201328. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2026.06.003 Full text : Here Oral body temperature and cerebrospinal fluid pTau181 in&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=3484"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3484\/revisions"}],"predecessor-version":[{"id":3486,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3484\/revisions\/3486"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/3220"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=3484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=3484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=3484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}