{"id":3462,"date":"2026-03-16T15:29:54","date_gmt":"2026-03-16T19:29:54","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3462"},"modified":"2026-03-16T15:29:54","modified_gmt":"2026-03-16T19:29:54","slug":"longitudinal-association-between-sleep-and-alzheimers-pathology-mohammediyan-et-al-2026","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2026\/03\/16\/longitudinal-association-between-sleep-and-alzheimers-pathology-mohammediyan-et-al-2026\/","title":{"rendered":"Longitudinal association between sleep and Alzheimer&rsquo;s pathology (Mohammediyan et al., 2026)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3463\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg\" width=\"761\" height=\"1000\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg 761w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_-228x300.jpg 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_-9x12.jpg 9w\" sizes=\"auto, (max-width: 761px) 100vw, 761px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br><\/span>Mohammediyan, B., Baril, A. A., Fajardo Valdez, A., St-Onge, F., Pichet Binette, A., Carrier, J., Geddes, M. R., Ducharme, S., Montembeault, M., Soucy, J. P., Breitner, J., Poirier, J., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2026). Longitudinal association between sleep and Alzheimer&rsquo;s pathology.&nbsp;<em>Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association<\/em>,&nbsp;<em>22<\/em>(3), e71228. https:\/\/doi.org\/10.1002\/alz.71228<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1002\/alz.71228\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1002-alz-71228-span-style-color-var-ast-global-color-0-class-stk-highlight-longitudinal-association-between-sleep-and-alzheimers-pathology-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1002\/alz.71228\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Longitudinal association between sleep and Alzheimer&rsquo;s pathology<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Bery Mohammediyan, Andr\u00e9e\u2010Ann Baril, Alfonso Fajardo Valdez, Fr\u00e9d\u00e9ric St\u2010Onge, Alexa Pichet Binette, Julie Carrier, Maiya R Geddes, Simon Ducharme, Maxime Montembeault, Jean\u2010Paul Soucy, John Breitner, Judes Poirier, Sylvia Villeneuve; for the PREVENT\u2010AD Research Group<\/strong><br>published in <em>Alzheimer&rsquo;s &amp; Dementia<\/em>, March 2026. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Introduction <\/strong>Since sleep disturbance is a modifiable risk factor for Alzheimer&rsquo;s disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons.<br><br><strong>Methods <\/strong>We included 223 participants from the PREVENT\u2010AD cohort with self\u2010reported measures of sleep, objective actigraphy measures of sleep, and positron emission tomography (PET) scans for AD pathology quantification. Repeated PET scans (mean follow\u2010up: 4.31 \u00b1 0.55 years) were available for 103 participants. We conducted robust linear models (RLM) for cross\u2010sectional analyses and RLMs using the annual change in AD pathology for longitudinal analyses.<br><br><strong>Results <\/strong>All actigraphy\u2010based sleep variability measures were associated with tau burden (duration: \u03b2 = 0.121 [95% confidence interval {CI} = 0.010; 0.232], p = 0.034; efficiency: 0.122 [0.010; 0.235], 0.033; fragmentation: 0.115 [0.010; 0.221], 0.033). Greater variability in sleep fragmentation was also associated with amyloid burden (0.074 [0.008; 0.140], 0.028), and variability in sleep efficiency portended amyloid burden and faster accumulation over time (0.075 [0.009; 0.141], 0.026; 0.164 [0.008; 0.320], 0.039; respectively).<br><br><strong>Discussion <\/strong>Irregularity in sleep patterns is associated with higher pathological burden and faster amyloid accumulation.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Mohammediyan, B., Baril, A. A., Fajardo Valdez, A., St-Onge, F., Pichet Binette, A., Carrier, J., Geddes, M. R., Ducharme, S., Montembeault, M., Soucy, J. P., Breitner, J., Poirier, J., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2026). Longitudinal association between sleep and Alzheimer&rsquo;s pathology.&nbsp;Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association,&nbsp;22(3), e71228. [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":3463,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[24,9],"tags":[15],"class_list":["post-3462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-24","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg",761,1000,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_-228x300.jpg",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg",761,1000,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg",761,1000,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg",761,1000,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_.jpg",761,1000,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/alz.v22.3.cover_-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Mohammediyan, B., Baril, A. A., Fajardo Valdez, A., St-Onge, F., Pichet Binette, A., Carrier, J., Geddes, M. R., Ducharme, S., Montembeault, M., Soucy, J. P., Breitner, J., Poirier, J., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2026). Longitudinal association between sleep and Alzheimer&rsquo;s pathology.&nbsp;Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association,&nbsp;22(3), e71228.&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=3462"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3462\/revisions"}],"predecessor-version":[{"id":3485,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3462\/revisions\/3485"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/3463"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=3462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=3462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=3462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}