{"id":3342,"date":"2026-03-11T11:21:20","date_gmt":"2026-03-11T15:21:20","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3342"},"modified":"2026-03-11T12:12:03","modified_gmt":"2026-03-11T16:12:03","slug":"study-design-features-increase-replicability-in-brain-wide-association-studies-kang-et-al-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2026\/03\/11\/study-design-features-increase-replicability-in-brain-wide-association-studies-kang-et-al-2024\/","title":{"rendered":"Study design features increase replicability in brain-wide association studies (Kang et al., 2024)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3344\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png\" width=\"440\" height=\"584\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png 440w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043-226x300.png 226w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043-9x12.png 9w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Kang, K., Seidlitz, J., Bethlehem, R. A., Xiong, J., Jones, M. T., Mehta, K., Keller, A. S., Tao, R., Randolph, A., Larsen, B., Tervo-Clemmens, B., Feczko, E., Dominguez, O. M., Nelson, S. M., Lifespan Brain Chart Consortium, Alexander-Bloch, A. F., Fair, D. A., Schildcrout, J., Fair, D. A., \u2026 Vandekar, S. (2024). Study design features increase replicability in brain-wide association studies. <em>Nature<\/em>, <em>636<\/em>(8043), 719\u2013727. https:\/\/doi.org\/10.1038\/s41586-024-08260-9<br><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1038\/s41586-024-08260-9\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1038-s-41586-024-08260-9-span-style-color-var-ast-global-color-0-class-stk-highlight-study-design-features-increase-replicability-in-brain-wide-association-studies-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1038\/s41586-024-08260-9\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Study design features increase replicability in brain-wide association studies<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Kaidi Kang, Jakob Seidlitz, Richard A. I. Bethlehem, Jiangmei Xiong, Megan T. Jones, Kahini Mehta, Arielle S. Keller, Ran Tao, Anita Randolph, Bart Larsen, Brenden Tervo-Clemmens, Eric Feczko, Oscar Miranda Dominguez, Steven M. Nelson, Lifespan Brain Chart Consortium, Jonathan Schildcrout, Damien A. Fair, Theodore D. Satterthwaite, Aaron Alexander-Bloch &amp; Simon Vandekar<\/strong><br><br>published in <em>Nature<\/em>, November 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Brain-wide association studies (BWAS) are a fundamental tool in discovering brain\u2013behaviour associations<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR1\">1<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR2\">2<\/a><\/sup>. Several recent studies have shown that thousands of study participants are required for good replicability of BWAS<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR1\">1<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR2\">2<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR3\">3<\/a><\/sup>. Here we performed analyses and meta-analyses of a robust effect size index using 63 longitudinal and cross-sectional MRI studies from the Lifespan Brain Chart Consortium<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08260-9#ref-CR4\">4<\/a><\/sup>\u00a0(77,695 total scans) to demonstrate that optimizing study design is critical for increasing standardized effect sizes and replicability in BWAS. A meta-analysis of brain volume associations with age indicates that BWAS with larger variability of the covariate and longitudinal studies have larger reported standardized effect size. Analysing age effects on global and regional brain measures from the UK Biobank and the Alzheimer\u2019s Disease Neuroimaging Initiative, we showed that modifying study design through sampling schemes improves standardized effect sizes and replicability. To ensure that our results are generalizable, we further evaluated the longitudinal sampling schemes on cognitive, psychopathology and demographic associations with structural and functional brain outcome measures in the Adolescent Brain and Cognitive Development dataset. We demonstrated that commonly used longitudinal models, which assume equal between-subject and within-subject changes can, counterintuitively, reduce standardized effect sizes and replicability. Explicitly modelling the between-subject and within-subject effects avoids conflating them and enables optimizing the standardized effect sizes for each separately. Together, these results provide guidance for study designs that improve the replicability of BWAS.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Kang, K., Seidlitz, J., Bethlehem, R. A., Xiong, J., Jones, M. T., Mehta, K., Keller, A. S., Tao, R., Randolph, A., Larsen, B., Tervo-Clemmens, B., Feczko, E., Dominguez, O. M., Nelson, S. M., Lifespan Brain Chart Consortium, Alexander-Bloch, A. F., Fair, D. A., Schildcrout, J., Fair, D. A., \u2026 Vandekar, S. (2024). Study [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":3344,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-3342","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png",440,584,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043-226x300.png",226,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png",440,584,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png",440,584,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png",440,584,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043.png",440,584,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/8043-9x12.png",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Kang, K., Seidlitz, J., Bethlehem, R. A., Xiong, J., Jones, M. T., Mehta, K., Keller, A. S., Tao, R., Randolph, A., Larsen, B., Tervo-Clemmens, B., Feczko, E., Dominguez, O. M., Nelson, S. M., Lifespan Brain Chart Consortium, Alexander-Bloch, A. F., Fair, D. A., Schildcrout, J., Fair, D. A., \u2026 Vandekar, S. (2024). 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