{"id":3160,"date":"2025-03-04T14:36:00","date_gmt":"2025-03-04T19:36:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3160"},"modified":"2025-09-16T13:28:01","modified_gmt":"2025-09-16T17:28:01","slug":"uncovering-atrophy-progression-pattern-and-mechanisms-in-individuals-at-risk-of-alzheimers-disease-tremblay-c-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2025\/03\/04\/uncovering-atrophy-progression-pattern-and-mechanisms-in-individuals-at-risk-of-alzheimers-disease-tremblay-c-et-al-2025\/","title":{"rendered":"Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer\u2019s disease. (Tremblay C. et Al., 2025)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3151\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025.jpeg\" width=\"1982\" height=\"2560\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025.jpeg 1982w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-232x300.jpeg 232w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-793x1024.jpeg 793w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-768x992.jpeg 768w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-1189x1536.jpeg 1189w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-1586x2048.jpeg 1586w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-9x12.jpeg 9w\" sizes=\"auto, (max-width: 1982px) 100vw, 1982px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Tremblay, C., Rahayel, S., Pastor-Bernier, A., St-Onge, F., Vo, A., Rheault, F., Daneault, V., Morys, F., Rajah, N., Villeneuve, S., Dagher, A., PREVENT-AD Research Group , &amp; Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) (2025). Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer&rsquo;s disease. <em>Brain communications<\/em>, <em>7<\/em>(2), fcaf099. https:\/\/doi.org\/10.1093\/braincomms\/fcaf099<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcaf099\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1093-braincomms-fcaf-099-span-style-color-var-ast-global-color-0-class-stk-highlight-uncovering-atrophy-progression-pattern-and-mechanisms-in-individuals-at-risk-of-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcaf099\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer\u2019s disease.<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Tremblay, C., Rahayel, S., Pastor-Bernier, A., St-Onge, F., Vo, A., Rheault, F., Daneault, V., Morys, F., Rajah, N., Villeneuve, S., Dagher, A., PREVENT-AD Research Group , &amp; Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI)<\/strong><br>published in <em>Brain Communications<\/em>, March 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Alzheimer&rsquo;s disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer&rsquo;s disease pathophysiology. Alzheimer&rsquo;s disease pathology is thought to arise from a combination of protein accumulation and spreading via neural connections, but how these processes influence brain atrophy progression in the pre-symptomatic phases remains unclear. Individuals with a family history of Alzheimer&rsquo;s disease (FHAD) have an elevated risk of Alzheimer&rsquo;s disease, providing an opportunity to study the pre-symptomatic phase. Here, we used structural MRI from three databases (Alzheimer&rsquo;s Disease Neuroimaging Initiative, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease and Montreal Adult Lifespan Study) to map atrophy progression in FHAD and Alzheimer&rsquo;s disease and assess the constraining effects of structural connectivity on atrophy progression. Cross-sectional and longitudinal data up to 4 years were used to perform atrophy progression analysis in FHAD and Alzheimer&rsquo;s disease compared with controls. PET radiotracers were also used to quantify the distribution of abnormal tau and amyloid-beta protein isoforms at baseline. We first derived cortical atrophy progression maps using deformation-based morphometry from 153 FHAD, 156 Alzheimer&rsquo;s disease and 116 controls with similar age, education and sex at baseline. We next examined the spatial relationship between atrophy progression and spatial patterns of tau aggregates and amyloid-beta plaques deposition, structural connectivity and neurotransmitter receptor and transporter distributions. Our results show that there were similar patterns of atrophy progression in FHAD and Alzheimer&rsquo;s disease, notably in the cingulate, temporal and parietal cortices, with more widespread and severe atrophy in Alzheimer&rsquo;s disease. Both tau and amyloid-beta pathology tended to accumulate in regions that were structurally connected in FHAD and Alzheimer&rsquo;s disease. The pattern of atrophy and its progression also aligned with existing structural connectivity in FHAD. In Alzheimer&rsquo;s disease, our findings suggest that atrophy progression results from pathology propagation that occurred earlier, on a previously intact connectome. Moreover, a relationship was found between serotonin receptor spatial distribution and atrophy progression in Alzheimer&rsquo;s disease. The current study demonstrates that regions showing atrophy progression in FHAD and Alzheimer&rsquo;s disease present with specific connectivity and cellular characteristics, uncovering some of the mechanisms involved in pre-clinical and clinical neurodegeneration.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Tremblay, C., Rahayel, S., Pastor-Bernier, A., St-Onge, F., Vo, A., Rheault, F., Daneault, V., Morys, F., Rajah, N., Villeneuve, S., Dagher, A., PREVENT-AD Research Group , &amp; Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) (2025). Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer&rsquo;s disease. Brain communications, 7(2), fcaf099. https:\/\/doi.org\/10.1093\/braincomms\/fcaf099 Full text [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3151,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3160","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025.jpeg",1982,2560,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-150x150.jpeg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-232x300.jpeg",232,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-768x992.jpeg",768,992,true],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-793x1024.jpeg",793,1024,true],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-1189x1536.jpeg",1189,1536,true],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-1586x2048.jpeg",1586,2048,true],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Brain-communication_2025-9x12.jpeg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Tremblay, C., Rahayel, S., Pastor-Bernier, A., St-Onge, F., Vo, A., Rheault, F., Daneault, V., Morys, F., Rajah, N., Villeneuve, S., Dagher, A., PREVENT-AD Research Group , &amp; Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) (2025). Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer&rsquo;s disease. Brain communications, 7(2), fcaf099. https:\/\/doi.org\/10.1093\/braincomms\/fcaf099 Full text&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=3160"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3160\/revisions"}],"predecessor-version":[{"id":3231,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/3160\/revisions\/3231"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/3151"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=3160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=3160"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=3160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}