{"id":2991,"date":"2024-09-01T16:32:00","date_gmt":"2024-09-01T20:32:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2991"},"modified":"2025-04-22T10:20:06","modified_gmt":"2025-04-22T14:20:06","slug":"neurochemical-organization-of-cortical-proteinopathy-and-neurophysiology-along-the-alzheimers-disease-continuum","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2024\/09\/01\/neurochemical-organization-of-cortical-proteinopathy-and-neurophysiology-along-the-alzheimers-disease-continuum\/","title":{"rendered":"Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer&rsquo;s disease continuum. (Weisman et al., 2024)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2984\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg\" width=\"761\" height=\"1000\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg 761w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-228x300.jpg 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-9x12.jpg 9w\" sizes=\"auto, (max-width: 761px) 100vw, 761px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Wiesman, A. I., Gallego-Rudolf, J., Villeneuve, S., Baillet, S., Wilson, T. W., &amp; PREVENT\u2010AD Research Group (2024). Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer&rsquo;s disease continuum. <em>Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association<\/em>, <em>20<\/em>(9), 6316\u20136331. https:\/\/doi.org\/10.1002\/alz.14110<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39001629\/\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-pubmed-ncbi-nlm-nih-gov-39001629-span-style-color-var-ast-global-color-0-class-stk-highlight-neurochemical-organization-of-cortical-proteinopathy-and-neurophysiology-along-the-alzheimers-disease-continuum-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39001629\/\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer&rsquo;s disease continuum <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Weisman A, Gallego-Rudolf J, Villeneuve S, Baillet S, Wilson T.W, PREVENT-AD research group<\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Alzheimer&rsquo;s &amp; Dementia<\/em>, September 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-f19939e\" data-block-id=\"f19939e\"><style>.stk-f19939e .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-f19939e .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>Despite parallel research indicating amyloid-\u03b2 accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer&rsquo;s disease (AD), the relationships between these phenomena remains unclear. Using magnetoencephalography, positron emission tomography, and an atlas of 19 neurotransmitters, we studied the alignment between neurophysiological alterations, amyloid-\u03b2 deposition, and the neurochemical gradients of the cortex. In patients with mild cognitive impairment and AD, changes in cortical rhythms were topographically aligned with cholinergic, serotonergic, and dopaminergic systems. These alignments correlated with the severity of clinical impairments. Additionally, cortical amyloid-\u03b2 plaques were preferentially deposited along neurochemical boundaries, influencing how neurophysiological alterations align with muscarinic acetylcholine receptors. Most of the amyloid-\u03b2-neurochemical and alpha-band neuro-physio-chemical alignments replicated in an independent dataset of individuals with asymptomatic amyloid-\u03b2 accumulation. Our findings demonstrate that AD pathology aligns topographically with the cortical distribution of chemical neuromodulator systems and scales with clinical severity, with implications for potential pharmacotherapeutic pathways. Changes in cortical rhythms in Alzheimer&rsquo;s are organized along neurochemical boundaries. The strength of these alignments is related to clinical symptom severity. Deposition of amyloid-\u03b2 (A\u03b2) is aligned with similar neurotransmitter systems. A\u03b2 deposition mediates the alignment of beta rhythms with cholinergic systems. Most alignments replicate in participants with pre-clinical Alzheimer&rsquo;s pathology.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Wiesman, A. I., Gallego-Rudolf, J., Villeneuve, S., Baillet, S., Wilson, T. W., &amp; PREVENT\u2010AD Research Group (2024). Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer&rsquo;s disease continuum. Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association, 20(9), 6316\u20136331. https:\/\/doi.org\/10.1002\/alz.14110 Full text : Here Neurochemical organization of cortical proteinopathy and neurophysiology [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2984,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-228x300.jpg",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Wiesman, A. I., Gallego-Rudolf, J., Villeneuve, S., Baillet, S., Wilson, T. W., &amp; PREVENT\u2010AD Research Group (2024). Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer&rsquo;s disease continuum. Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association, 20(9), 6316\u20136331. https:\/\/doi.org\/10.1002\/alz.14110 Full text : Here Neurochemical organization of cortical proteinopathy and neurophysiology&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=2991"}],"version-history":[{"count":6,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2991\/revisions"}],"predecessor-version":[{"id":3134,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2991\/revisions\/3134"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/2984"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=2991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=2991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=2991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}