{"id":2962,"date":"2024-05-09T10:15:57","date_gmt":"2024-05-09T14:15:57","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2962"},"modified":"2025-04-22T09:50:17","modified_gmt":"2025-04-22T13:50:17","slug":"ventromedial-frontoinsular-connectivity-is-associated-with-long-term-smoking-behaviour-change-in-aging-thovinakere-et-al-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2024\/05\/09\/ventromedial-frontoinsular-connectivity-is-associated-with-long-term-smoking-behaviour-change-in-aging-thovinakere-et-al-2024\/","title":{"rendered":"Ventromedial Frontoinsular Connectivity is Associated with Long-term Smoking Behaviour Change in Aging. (Thovinakere et al., 2024)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2963\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png\" width=\"520\" height=\"670\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png 520w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453-233x300.png 233w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453-9x12.png 9w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br> Thovinakere N., Ai M., de la Colina A.N, Walker C., Baracchini G., Tremblay-Mercier J., Villeneuve S., Spreng N., Geddes M.R., Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging. <em><em>Imaging Neuroscience<\/em><\/em> 2024; 2 1\u201320. doi: <a href=\"https:\/\/doi.org\/10.1162\/imag_a_00142\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1162\/imag_a_00142<\/a>hovinakere et al., (2024). Ventromedial frontoinsular connectivity is associated with long-term smoking behaviour change in aging.\u00a0<em>Imaging Neurosciences.<\/em><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/direct.mit.edu\/imag\/article\/doi\/10.1162\/imag_a_00142\/120468\/Ventromedial-frontoinsular-connectivity-is\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-direct-mit-edu-imag-article-doi-10-1162-imag-a-00142-120468-ventromedial-frontoinsular-connectivity-is-span-style-color-var-ast-global-color-0-class-stk-highlight-ventromedial-frontoinsular-connectivity-is-associated-with-long-term-smoking-behaviour-change-in-aging-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/direct.mit.edu\/imag\/article\/doi\/10.1162\/imag_a_00142\/120468\/Ventromedial-frontoinsular-connectivity-is\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Ventromedial Frontoinsular Connectivity is Associated with Long-term Smoking Behaviour Change in Aging <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Thovinakere N, Ai M, de la Colina A.N,  Walker C, Baracchini J, Tremblay-Mercier J, Villeneuve S, Spreng N, Geddes M.R. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Imaging Neurosciences<\/em>, May 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-3419d37\" data-block-id=\"3419d37\"><style>.stk-3419d37 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-3419d37 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>A central question in the field of cognitive aging and behavioral neuroscience is what enables some individuals to successfully change their behavior more than others? Smoking is a significant risk factor for cognitive decline, particularly in vulnerable populations, including those who are at an elevated risk for Alzheimer\u2019s disease (AD). Developing effective smoking reduction strategies is therefore a public health priority. The goal of the current study is to better understand the brain mechanisms underlying long-term smoking behavior change in cognitively normal, but at-risk, older adults. Neuroimaging and human lesion studies have implicated the insula and its functional network in subjective interoceptive awareness of cigarette craving and smoking-cue reactivity. We sought to characterize the extent to which anterior insular resting-state functional connectivity (RSFC) MRI predicted long-term smoking reduction (mean: 2.7 years, range 8 months\u20134 years) using a seed-to-voxel approach. Twenty-three (18 women; 26% APOE4 carriers; 61.5 years, SD = 3.7) cognitively unimpaired older individuals who smoked cigarettes at their baseline visit and have a first-degree family history of AD (at least one parent or multiple siblings affected) were included from a prospective longitudinal cohort, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease (PREVENT-AD) in the current study. We found that reduced long-term smoking behavior was associated with enhanced antagonistic RSFC between bilateral anterior insula (aINS) and ventromedial prefrontal cortex (vmPFC). In a second pre-registered replication study within a larger, independent sample of 118 cognitively normal older adults who smoked cigarettes at baseline from the UK Biobank (73 women; 27.9% APOE4 carriers; 60.3 years, SD = 2.7), we found that baseline enhanced antagonistic RSFC between anterior insula and vmPFC predicted long-term smoking reduction (mean 5.2 years; ranging from 3 years to 7 years). To our knowledge, this is the largest study to examine the neural substrates of long-term smoking cessation in human aging. Our results suggest that antagonistic RSFC between aINS and vmPFC is a brain marker of future smoking reduction and disease prevention in older adults at risk for AD.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Thovinakere N., Ai M., de la Colina A.N, Walker C., Baracchini G., Tremblay-Mercier J., Villeneuve S., Spreng N., Geddes M.R., Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging. Imaging Neuroscience 2024; 2 1\u201320. doi: https:\/\/doi.org\/10.1162\/imag_a_00142hovinakere et al., (2024). Ventromedial frontoinsular connectivity is associated with long-term smoking behaviour change in [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2963,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2962","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png",520,670,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453-233x300.png",233,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png",520,670,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png",520,670,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png",520,670,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453.png",520,670,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/IMAG_cover-1980937453-9x12.png",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Thovinakere N., Ai M., de la Colina A.N, Walker C., Baracchini G., Tremblay-Mercier J., Villeneuve S., Spreng N., Geddes M.R., Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging. Imaging Neuroscience 2024; 2 1\u201320. doi: https:\/\/doi.org\/10.1162\/imag_a_00142hovinakere et al., (2024). Ventromedial frontoinsular connectivity is associated with long-term smoking behaviour change in&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=2962"}],"version-history":[{"count":7,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2962\/revisions"}],"predecessor-version":[{"id":3110,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2962\/revisions\/3110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/2963"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=2962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=2962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=2962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}