{"id":2779,"date":"2024-05-28T00:00:24","date_gmt":"2024-05-28T04:00:24","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2779"},"modified":"2025-04-16T12:38:56","modified_gmt":"2025-04-16T16:38:56","slug":"locus-coeruleus-integrity-is-related-to-an-exploitation-based-decision-making-bias-in-older-adulthood-turner-gr-et-al-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2024\/05\/28\/locus-coeruleus-integrity-is-related-to-an-exploitation-based-decision-making-bias-in-older-adulthood-turner-gr-et-al-2024\/","title":{"rendered":"Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood. (Turner GR. et al., 2024)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width:768px){.stk-0bb6bd7{flex:var(--stk-flex-grow,1) 1 calc(25% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2782\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas.webp\" width=\"807\" height=\"1088\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas.webp 807w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-223x300.webp 223w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-760x1024.webp 760w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-768x1035.webp 768w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-9x12.webp 9w\" sizes=\"auto, (max-width: 807px) 100vw, 807px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Turner, G. R., Hewan, P., Wearn, A., van Dooren, R., Wyatt, L., Leppert, I. R., Baracchini, G., Hughes, C., Williams, K. M., Sylvain, E., Tremblay-Mercier, J., Poirier, J., Villeneuve, S., Tardif, C., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.\u00a0<em>Proceedings of the National Academy of Sciences of the United States of America<\/em>,\u00a0<em>121<\/em>(22), e2322617121. https:\/\/doi.org\/10.1073\/pnas.2322617121<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2322617121?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width:768px){.stk-36f0c6d{flex:var(--stk-flex-grow,1) 1 calc(75% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-pubmed-ncbi-nlm-nih-gov-38771873-target-blank-rel-noreferrer-noopener-span-style-color-var-ast-global-color-0-class-stk-highlight-strong-locus-coeruleus-integrity-is-related-to-an-exploitation-based-decision-making-bias-in-older-adulthood-strong-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38771873\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\"><strong>Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood<\/strong>. <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Turner GR., Hewan P., Wearn A., van Dooren R., Wyatt L., Leppert IR., Baracchini G., Hughes C., Williams K M., Sylvain E., Tremblay-Mercier J., Poirier J., Villeneuve S., Tardif C., Spreng RN., &amp; PREVENT-AD Research Group<\/strong><br><br>published in <em>PNAS<\/em>, May 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI-magnetic transfer saturation\u2014we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer\u2019s disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer\u2019s related decline, may fundamentally alter decision-making abilities in later life.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Turner, G. R., Hewan, P., Wearn, A., van Dooren, R., Wyatt, L., Leppert, I. R., Baracchini, G., Hughes, C., Williams, K. M., Sylvain, E., Tremblay-Mercier, J., Poirier, J., Villeneuve, S., Tardif, C., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.\u00a0Proceedings [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas.webp",807,1088,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-150x150.webp",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-223x300.webp",223,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-768x1035.webp",768,1035,true],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-760x1024.webp",760,1024,true],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas.webp",807,1088,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas.webp",807,1088,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/05\/pnas-9x12.webp",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Turner, G. R., Hewan, P., Wearn, A., van Dooren, R., Wyatt, L., Leppert, I. R., Baracchini, G., Hughes, C., Williams, K. M., Sylvain, E., Tremblay-Mercier, J., Poirier, J., Villeneuve, S., Tardif, C., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.\u00a0Proceedings&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=2779"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2779\/revisions"}],"predecessor-version":[{"id":2784,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2779\/revisions\/2784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/2782"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=2779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=2779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=2779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}