{"id":2051,"date":"2024-04-02T15:12:17","date_gmt":"2024-04-02T19:12:17","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2051"},"modified":"2024-05-08T17:28:12","modified_gmt":"2024-05-08T21:28:12","slug":"structural-white-matter-properties-and-cognitive-resilience-to-tau-pathology-qiu-t-et-al-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2024\/04\/02\/structural-white-matter-properties-and-cognitive-resilience-to-tau-pathology-qiu-t-et-al-2024\/","title":{"rendered":"Structural white matter properties and cognitive resilience to tau pathology. (Qiu T. et al., 2024)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width:768px){.stk-0bb6bd7{flex:1 1 calc(25% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2052\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp\" width=\"650\" height=\"855\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp 650w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz-228x300.webp 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz-9x12.webp 9w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Qiu, T., Liu, Z. Q., Rheault, F., Legarreta, J. H., Valcourt Caron, A., St-Onge, F., Strikwerda-Brown, C., Metz, A., Dadar, M., Soucy, J. P., Pichet Binette, A., Spreng, R. N., Descoteaux, M., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2024). Structural white matter properties and cognitive resilience to tau pathology.\u00a0<em>Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association<\/em>, 10.1002\/alz.13776. Advance online publication. https:\/\/doi.org\/10.1002\/alz.13776<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13776\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width:768px){.stk-36f0c6d{flex:1 1 calc(75% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-alz-journals-onlinelibrary-wiley-com-doi-10-1002-alz-13776-target-blank-rel-noreferrer-noopener-span-style-color-var-ast-global-color-0-class-stk-highlight-structural-white-matter-properties-and-cognitive-resilience-to-tau-pathology-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.13776\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Structural white matter properties and cognitive resilience to tau pathology. <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Qiu T, Liu ZQ, Rheault F, Legarreta JH, Valcourt Caron A, St-Onge F, Strikwerda-Brown C, Metz A, Dadar M, Soucy JP, Pichet Binette A, Spreng RN, Descoteaux M, Villeneuve S; PREVENT\u2010AD Research Group.<\/strong><br><br>published in <em>Alzheimer&rsquo;s &amp; Dementia<\/em>, April 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><strong>Introduction:\u00a0<\/strong>We assessed whether macro- and\/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer&rsquo;s disease pathology years prior to clinical onset.<br><strong>Methods:\u00a0<\/strong>We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-\u03b2\/tau pathology and cognitive decline. We also investigated whether demographic and health\/risk factors are associated with white matter properties.<br><strong>Results:\u00a0<\/strong>Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks.<br><strong>Discussion:\u00a0<\/strong>White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties.<br><strong>Highlights:\u00a0<\/strong>A\u03b2 and tau were associated with longitudinal memory change over \u223c7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health\/risk factors were associated with white matter properties.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Qiu, T., Liu, Z. Q., Rheault, F., Legarreta, J. H., Valcourt Caron, A., St-Onge, F., Strikwerda-Brown, C., Metz, A., Dadar, M., Soucy, J. P., Pichet Binette, A., Spreng, R. N., Descoteaux, M., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2024). Structural white matter properties and cognitive resilience to tau pathology.\u00a0Alzheimer&rsquo;s &amp; dementia : the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2052,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp",650,855,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz-150x150.webp",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz-228x300.webp",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp",650,855,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp",650,855,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp",650,855,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz.webp",650,855,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/alz-9x12.webp",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Qiu, T., Liu, Z. Q., Rheault, F., Legarreta, J. H., Valcourt Caron, A., St-Onge, F., Strikwerda-Brown, C., Metz, A., Dadar, M., Soucy, J. P., Pichet Binette, A., Spreng, R. N., Descoteaux, M., Villeneuve, S., &amp; PREVENT\u2010AD Research Group (2024). Structural white matter properties and cognitive resilience to tau pathology.\u00a0Alzheimer&rsquo;s &amp; dementia : the&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=2051"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2051\/revisions"}],"predecessor-version":[{"id":2189,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2051\/revisions\/2189"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/2052"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=2051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=2051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=2051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}