{"id":2032,"date":"2024-02-16T14:40:03","date_gmt":"2024-02-16T19:40:03","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2032"},"modified":"2024-05-08T17:29:45","modified_gmt":"2024-05-08T21:29:45","slug":"day-to-day-sleep-variability-with-alzheimers-biomarkers-in-at-risk-elderly","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/fr\/2024\/02\/16\/day-to-day-sleep-variability-with-alzheimers-biomarkers-in-at-risk-elderly\/","title":{"rendered":"Day-to-day sleep variability with Alzheimer\u2019s biomarkers in at-risk elderly. (Baril AA. et al., 2024)"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width:768px){.stk-0bb6bd7{flex:1 1 calc(25% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2033\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png\" width=\"650\" height=\"880\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png 650w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024-222x300.png 222w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024-9x12.png 9w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Ashton, N. J., Zetterberg, H., Blennow, K., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT\u2010AD Research Group (2024). Day-to-day sleep variability with Alzheimer&rsquo;s biomarkers in at-risk elderly.&nbsp;<em>Alzheimer&rsquo;s &amp; dementia (Amsterdam, Netherlands)<\/em>,&nbsp;<em>16<\/em>(1), e12521. https:\/\/doi.org\/10.1002\/dad2.12521<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-dfcda88\" data-block-id=\"dfcda88\"><style>.stk-dfcda88 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-dfcda88 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text :<\/span><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12521\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"color: #0693e3;\" class=\"stk-highlight\"> <\/span>Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width:768px){.stk-36f0c6d{flex:1 1 calc(75% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-alz-journals-onlinelibrary-wiley-com-doi-10-1002-dad-2-12521-target-blank-rel-noreferrer-noopener-span-style-color-var-ast-global-color-0-class-stk-highlight-day-to-day-sleep-variability-with-alzheimers-biomarkers-in-at-risk-elderly-span-a-a-href-https-doi-org-10-1093-braincomms-fcae-031-span-style-color-var-ast-global-color-0-class-stk-highlight-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12521\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Day-to-day sleep variability with Alzheimer\u2019s biomarkers in at-risk elderly.<\/span><\/a><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcae031\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\"> <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Baril AA, Picard C, Labont\u00e9 A, Sanchez E, Duclos C, Mohammediyan B, Ashton NJ, Zetterberg H, Blennow K, Breitner JCS, Villeneuve S, Poirier J; PREVENT\u2010AD Research Group.<\/strong><br><br>published in dans <em>Alzheimer&rsquo;s<\/em>\u00a0<em>&amp; Dementia<\/em>, February 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><strong>Introduction:&nbsp;<\/strong>Measuring day-to-day sleep variability might reveal unstable sleep-wake cycles reflecting neurodegenerative processes. We evaluated the association between Alzheimer&rsquo;s disease (AD) fluid biomarkers with day-to-day sleep variability.<br><strong>Methods:&nbsp;<\/strong>In the PREVENT-AD cohort, 203 dementia-free participants (age: 68.3 \u00b1 5.4; 78 males) with a parental history of sporadic AD were tested with actigraphy and fluid biomarkers. Day-to-day variability (standard deviations over a week) was assessed for sleep midpoint, duration, efficiency, and nighttime activity count.<br><strong>Results:&nbsp;<\/strong>Lower cerebrospinal fluid (CSF) ApoE, higher CSF p-tau181\/amyloid-\u03b2 (A\u03b2)<sub>42<\/sub>, and higher plasma p-tau231\/A\u03b2<sub>42<\/sub>&nbsp;were associated with higher variability of sleep midpoint, sleep duration, and\/or activity count. The associations between fluid biomarkers with greater sleep duration variability were especially observed in those that carried the&nbsp;<em>APOE4<\/em>&nbsp;allele, mild cognitive impairment converters, or those with gray matter atrophy.<br><strong>Discussion:&nbsp;<\/strong>Day-to-day sleep variability were associated with biomarkers of AD in at-risk individuals, suggesting that unstable sleep promotes neurodegeneration or, conversely, that AD neuropathology disrupts sleep-wake cycles.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Citation : Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Ashton, N. J., Zetterberg, H., Blennow, K., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT\u2010AD Research Group (2024). Day-to-day sleep variability with Alzheimer&rsquo;s biomarkers in at-risk elderly.&nbsp;Alzheimer&rsquo;s &amp; dementia (Amsterdam, Netherlands),&nbsp;16(1), e12521. https:\/\/doi.org\/10.1002\/dad2.12521 Full text : Here Day-to-day [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2033,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png",650,880,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024-222x300.png",222,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png",650,880,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png",650,880,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png",650,880,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024.png",650,880,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/AlzheimerDementia-2024-9x12.png",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/fr\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Ashton, N. J., Zetterberg, H., Blennow, K., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT\u2010AD Research Group (2024). Day-to-day sleep variability with Alzheimer&rsquo;s biomarkers in at-risk elderly.&nbsp;Alzheimer&rsquo;s &amp; dementia (Amsterdam, Netherlands),&nbsp;16(1), e12521. https:\/\/doi.org\/10.1002\/dad2.12521 Full text : Here Day-to-day&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/comments?post=2032"}],"version-history":[{"count":8,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2032\/revisions"}],"predecessor-version":[{"id":2047,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/posts\/2032\/revisions\/2047"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media\/2033"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/media?parent=2032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/categories?post=2032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/fr\/wp-json\/wp\/v2\/tags?post=2032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}