{"id":3357,"date":"2026-03-11T13:56:02","date_gmt":"2026-03-11T17:56:02","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3357"},"modified":"2026-03-11T13:56:02","modified_gmt":"2026-03-11T17:56:02","slug":"associations-of-lifestyle-factors-with-amyloid-pathology-in-persons-without-dementia-oomens-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2026\/03\/11\/associations-of-lifestyle-factors-with-amyloid-pathology-in-persons-without-dementia-oomens-et-al-2025\/","title":{"rendered":"Associations of lifestyle factors with amyloid pathology in persons without dementia (Oomens et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><style>.stk-3a7774a .stk-img-wrapper{width:120px !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2208\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg\" width=\"120\" height=\"165\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg 120w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21-9x12.jpg 9w\" sizes=\"auto, (max-width: 120px) 100vw, 120px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., Engelborghs, S., Fladby, T., van der Flier, W. M., Frisoni, G. B., Fr\u00f6hlich, L., Gill, K. D., Grimmer, T., Hort, J., Itoh, Y., Iwatsubo, T., Klimkowicz-Mrowiec, A., Landau, S. M., Lee, D. Y., Lle\u00f3, A., \u2026 Jansen, W. J. (2025). Associations of lifestyle factors with amyloid pathology in persons without dementia. <em>Journal of Alzheimer\u2019s Disease<\/em>, <em>108<\/em>(3), 1043\u20131059. https:\/\/doi.org\/10.1177\/13872877251379083<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1177\/13872877251379083\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1177-13872877251379083-span-style-color-var-ast-global-color-0-class-stk-highlight-associations-of-lifestyle-factors-with-amyloid-pathology-in-persons-without-dementia-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1177\/13872877251379083\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Associations of lifestyle factors with amyloid pathology in persons without dementia<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Julie E Oomens, Stephanie JB Vos, Nancy N Maserejian, Merc\u00e8 Boada, Mira Didic, Sebastiaan Engelborghs, Tormod Fladby, Wiesje M van der Flier, Giovanni B Frisoni, Lutz Fr\u00f6hlich, Kiran Dip Gill, Timo Grimmer, Jakub Hort, Yoshiaki Itoh, Takeshi Iwatsubo, Aleksandra Klimkowicz-Mrowiec, Susan M Landau, Dong Young Lee, Alberto Lle\u00f3, Pablo Martinez-Lage, Alexandre de Mendon\u00e7a, Philipp T Meyer, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Julius Popp, Lorena Rami, Eric M Reiman, Juha O Rinne, Karen M Rodrigue, Pascual S\u00e1nchez-Juan, Isabel Santana, Nikolaos Scarmeas, Philip Scheltens, Ingmar Skoog, Reisa A Sperling, Yaakov Stern, Sylvia Villeneuve, Gunhild Waldemar, Jens Wiltfang, Henrik Zetterberg, Daniel Alcolea, Ricardo F Allegri, Daniele Altomare, Randall J Bateman, Simone Baiardi, Ines Baldeiras, Kaj Blennow, Anouk den Braber, Mark A van Buchem, Min Soo Byun, Ji\u0159\u00ed Cerman, Kewei Chen, Elena Chipi, Gregory S Day, Alexander Drzezga, Laura L Ekblad, Stefan F\u00f6rster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric Guedj, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jim\u00e9nez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bj\u00f8rn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marqui\u00e9, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, Eloy Rodr\u00edguez-Rodriguez, Agust\u00edn Ruiz, Eckart R\u00fcther, Jayant Sakhardande, Per Selnes, Dina Silva, Hilkka Soininen, Luiza Spiru, Akitoshi Takeda, Charlotte E Teunissen, Betty M Tijms, Lisa Vermunt, \u00c5sa K Wallin, Wietse Wiels, Mary Yannakoulia, Dahyun Yi, Anna Zettergren, for the Alzheimer&rsquo;s Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer&rsquo;s Dementia (EPAD) consortium, Fundaci\u00f3 ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer&rsquo;s Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer&rsquo;s Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer&rsquo;s Disease (PREVENT-AD) research group, Rik Ossenkoppele, Frans RJ Verhey, Pieter Jelle Visser, and Willemijn J Jansen<\/strong><br><br>published in <em>Journal of Alzheimer&rsquo;s Disease<\/em>, November 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Background<\/strong> The association between lifestyle factors and Alzheimer&rsquo;s disease (AD) pathophysiology remains incompletely understood.<br><br><strong>Objective<\/strong> The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.<br><br><strong>Methods<\/strong> For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.<br><br><strong>Results<\/strong> We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE \u03b54 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE \u03b54 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR\u2009=\u20090.77, 95%CI 0.66\u20130.89, p\u2009&lt;\u20090.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR\u2009=\u20090.85, 95%CI 0.73\u20130.99, p\u2009=\u20090.029; OR\u2009=\u20090.62, 95%CI 0.45\u20130.86, p\u2009=\u20090.004).<br><br><strong>Conclusions<\/strong> In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.<\/p><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., Engelborghs, S., Fladby, T., van der Flier, W. M., Frisoni, G. B., Fr\u00f6hlich, L., Gill, K. D., Grimmer, T., Hort, J., Itoh, Y., Iwatsubo, T., Klimkowicz-Mrowiec, A., Landau, S. M., Lee, D. Y., Lle\u00f3, A., \u2026 Jansen, W. J. (2025). [&hellip;]<\/p>","protected":false},"author":6,"featured_media":2208,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21-120x150.jpg",120,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21.jpg",120,165,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/04\/JAD_21-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., Engelborghs, S., Fladby, T., van der Flier, W. M., Frisoni, G. B., Fr\u00f6hlich, L., Gill, K. D., Grimmer, T., Hort, J., Itoh, Y., Iwatsubo, T., Klimkowicz-Mrowiec, A., Landau, S. M., Lee, D. Y., Lle\u00f3, A., \u2026 Jansen, W. J. (2025).&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3357"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3357\/revisions"}],"predecessor-version":[{"id":3358,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3357\/revisions\/3358"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2208"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}