{"id":3348,"date":"2026-03-11T12:35:08","date_gmt":"2026-03-11T16:35:08","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3348"},"modified":"2026-03-11T12:35:08","modified_gmt":"2026-03-11T16:35:08","slug":"longitudinal-effects-of-cerebrovascular-reactivity-and-cerebral-pulsatility-in-cognitively-intact-older-adults-with-apoe4-links-with-cognition-potvin-jutras-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2026\/03\/11\/longitudinal-effects-of-cerebrovascular-reactivity-and-cerebral-pulsatility-in-cognitively-intact-older-adults-with-apoe4-links-with-cognition-potvin-jutras-et-al-2025\/","title":{"rendered":"Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition (Potvin-Jutras et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><style>.stk-3a7774a .stk-img-wrapper{width:158px !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3349\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp\" width=\"158\" height=\"212\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp 158w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357-9x12.webp 9w\" sizes=\"auto, (max-width: 158px) 100vw, 158px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Potvin-Jutras, Z., Tremblay, P.-L., Mohammadi, H., Villeneuve, S., Spreng, R. N., Gauthier, C. J., &amp; PREVENT-AD Research Group. (2025). Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with Apoe4: Links with cognition. <em>GeroScience<\/em>. https:\/\/doi.org\/10.1007\/s11357-025-02036-3<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1007\/s11357-025-02036-3\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1007-s-11357-025-02036-3-span-style-color-var-ast-global-color-0-class-stk-highlight-longitudinal-effects-of-cerebrovascular-reactivity-and-cerebral-pulsatility-in-cognitively-intact-older-adults-with-apoe-4-links-with-cognition-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1007\/s11357-025-02036-3\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Potvin-Jutras+Z&amp;cauthor_id=41353310\">Zacharie Potvin-Jutras<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tremblay+PL&amp;cauthor_id=41353310\">Pierre-Luc Tremblay<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mohammadi+H&amp;cauthor_id=41353310\">Hanieh Mohammadi<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Villeneuve+S&amp;cauthor_id=41353310\">Sylvia Villeneuve<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Spreng+RN&amp;cauthor_id=41353310\">R Nathan Spreng<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Gauthier+CJ&amp;cauthor_id=41353310\">Claudine J Gauthier<\/a>;\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PREVENT-AD+Research+Group%5BCorporate+Author%5D\">PREVENT-AD Research Group<\/a><\/strong><br><br>published in <em>GeroScience<\/em>, December 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer\u2019s disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with aging and AD. However, the relationship between APOE4 status and these cerebrovascular metrics remains unclear. This study investigated whether the APOE genotype influences longitudinal changes in CVR and CP, and their association with cognitive performance in cognitively unimpaired individuals. We utilized the PREVENT-AD cohort, including 101 APOE4 carriers (30 males and 71 females) and 152 non-APOE4 carriers (48 males and 104 females) aged 55 and older. Relative CVR and CP were derived from resting state functional magnetic resonance imaging data, with regional values extracted from cerebral arterial territories. Results indicated significant interactions between APOE4 status and relative CVR in the left middle cerebral artery and left posterior cerebral artery (PCA) territories. APOE4 status disaggregated analyses revealed that APOE4 carriers uniquely presented a significant decline in relative CVR within the left PCA. Furthermore, sex-specific effects were identified, with female APOE4 carriers having lower relative CVR in the right anterior cerebral artery territory compared to female non-carriers. Importantly, higher relative CVR was positively associated with better cognitive performance in APOE4 carriers. No significant effects of APOE4 status on CP were found. Together, these findings suggest that relative CVR may be an important early measure of cerebrovascular health and cognition in cognitively intact APOE4 carriers.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Potvin-Jutras, Z., Tremblay, P.-L., Mohammadi, H., Villeneuve, S., Spreng, R. N., Gauthier, C. J., &amp; PREVENT-AD Research Group. (2025). Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with Apoe4: Links with cognition. GeroScience. https:\/\/doi.org\/10.1007\/s11357-025-02036-3 Full text : Here Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3349,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357-150x150.webp",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357.webp",158,212,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2026\/03\/11357-9x12.webp",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Potvin-Jutras, Z., Tremblay, P.-L., Mohammadi, H., Villeneuve, S., Spreng, R. N., Gauthier, C. J., &amp; PREVENT-AD Research Group. (2025). Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with Apoe4: Links with cognition. GeroScience. https:\/\/doi.org\/10.1007\/s11357-025-02036-3 Full text : Here Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3348"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3348\/revisions"}],"predecessor-version":[{"id":3350,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3348\/revisions\/3350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3349"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}