{"id":3346,"date":"2026-03-11T12:03:48","date_gmt":"2026-03-11T16:03:48","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3346"},"modified":"2026-03-13T14:09:16","modified_gmt":"2026-03-13T18:09:16","slug":"frequency-and-clinical-outcomes-associated-with-tau-positron-emission-tomography-positivity-moscoso-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2026\/03\/11\/frequency-and-clinical-outcomes-associated-with-tau-positron-emission-tomography-positivity-moscoso-et-al-2025\/","title":{"rendered":"Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity (Moscoso et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3430\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png 300w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-150x150.png 150w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-12x12.png 12w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Moscoso, A., Heeman, F., Raghavan, S., Costoya-S\u00e1nchez, A., van Essen, M., Mainta, I., Camacho, V., Rodr\u00edguez-Fonseca, O., Silva-Rodr\u00edguez, J., Perissinotti, A., Gu, Y., Yun, J., Peretti, D., Ribaldi, F., Coomans, E. M., Brum, W. S., Grothe, M. J., Aguiar, P., Bischof, G. N., \u2026 Alzheimer\u2019s Disease Neuroimaging Initiative. (2025). Frequency and clinical outcomes associated with tau positron emission tomography positivity. <em>JAMA<\/em>, <em>334<\/em>(3), 229. https:\/\/doi.org\/10.1001\/jama.2025.7817<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1001\/jama.2025.7817\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1001-jama-2025-7817-span-style-color-var-ast-global-color-0-class-stk-highlight-frequency-and-clinical-outcomes-associated-with-tau-positron-emission-tomography-positivity-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1001\/jama.2025.7817\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya-S\u00e1nchez, Martijn van Essen, Ismini Mainta, Valle Camacho, Omar Rodr\u00edguez-Fonseca, Jes\u00fas Silva-Rodr\u00edguez, Andr\u00e9s Perissinotti, Yuna Gu, Jihwan Yun, Debora Peretti, Federica Ribaldi, Emma M Coomans, Wagner S Brum, Michel J Grothe, Pablo Aguiar, G\u00e9rard N Bischof, Alexander Drzezga, Sang Won Seo, Sylvia Villeneuve, Maura Malpetti, John T O&rsquo;Brien, James B Rowe, Elsmarieke M van de Giessen, Rik Ossenkoppele, William J Jagust, Ruben Smith, Oskar Hansson, Giovanni B Frisoni, Valentina Garibotto, David N Soleimani-Meigooni, Maria Carrillo, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici, Liana G Apostolova, Pamela J LaMontagne, Michael J Pontecorvo, Keith A Johnson, Reisa A Sperling, Michael W Weiner, Ronald C Petersen, Clifford R Jack Jr, Prashanthi Vemuri, Michael Sch\u00f6ll; PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer\u2019s Disease Neuroimaging Initiative<\/strong><br><br>published in <em>JAMA<\/em>, June 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Importance<\/strong>&nbsp;&nbsp;Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD).<br><br><strong>Objective<\/strong>&nbsp;&nbsp;To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes.<br><br><strong>Design, Setting, and Participants<\/strong>&nbsp;&nbsp;Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514 participants from 13 countries, collected between January 2013 and June 2024. Cognitively unimpaired individuals and patients with a clinical diagnosis of mild cognitive impairment (MCI), AD dementia, or other neurodegenerative disorders were included.<br><br><strong>Exposures<\/strong>&nbsp;&nbsp;Tau PET with flortaucipir F 18, amyloid-\u03b2 (A\u03b2) PET, and clinical examinations. Tau PET scans were visually rated as positive according to a US Food and Drug Administration\u2013 and European Medicines Agency\u2013approved method, designed to indicate the presence of advanced neurofibrillary tangle pathology (Braak stages V-VI).<br><br><strong>Main Outcomes and Measures<\/strong>&nbsp;&nbsp;Frequency of tau PET positivity and absolute risk of clinical progression (eg, progression to MCI or dementia).<br><br><strong>Results<\/strong>&nbsp;&nbsp;Among the 6514 participants (mean age, 69.5 years; 50.5% female), median follow-up time ranged from 1.5 to 4.0 years. Of 3487 cognitively unimpaired participants, 349 (9.8%) were tau PET positive; the estimated frequency of tau PET positivity was less than 1% in those aged younger than 50 years, and increased from 3% (95% CI, 2%-4%) at 60 years to 19% (95% CI, 16%-24%) at 90 years. Tau PET positivity frequency estimates increased across MCI and AD dementia clinical diagnoses (43% [95% CI, 41%-46%] and 79% [95% CI, 77%-82%] at 75 years, respectively). Most tau PET\u2013positive individuals (92%) were also A\u03b2 PET positive. Cognitively unimpaired participants who were positive for both A\u03b2 PET and tau PET had a higher absolute risk of progression to MCI or dementia over the following 5 years (57% [95% CI, 45%-71%]) compared with both A\u03b2 PET\u2013positive\/tau PET\u2013negative (17% [95% CI, 13%-22%]) and A\u03b2 PET\u2013negative\/tau PET\u2013negative (6% [95% CI, 5%-8%]) individuals. Among participants with MCI at the time of the tau PET scan, an A\u03b2 PET\u2013positive\/tau PET\u2013positive profile was associated with a 5-year absolute risk of progression to dementia of 70% (95% CI, 59%-81%).<br><br><strong>Conclusions and Relevance<\/strong>&nbsp;&nbsp;In a large convenience sample, a positive tau PET scan occurred at a nonnegligible rate among cognitively unimpaired individuals, and the combination of A\u03b2 PET positivity and tau PET positivity was associated with a high risk of clinical progression in both preclinical and symptomatic stages of AD. These findings underscore the potential of tau PET as a biomarker for staging AD pathology.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Moscoso, A., Heeman, F., Raghavan, S., Costoya-S\u00e1nchez, A., van Essen, M., Mainta, I., Camacho, V., Rodr\u00edguez-Fonseca, O., Silva-Rodr\u00edguez, J., Perissinotti, A., Gu, Y., Yun, J., Peretti, D., Ribaldi, F., Coomans, E. M., Brum, W. S., Grothe, M. J., Aguiar, P., Bischof, G. N., \u2026 Alzheimer\u2019s Disease Neuroimaging Initiative. (2025). Frequency and clinical outcomes [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3430,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-12x12.png",12,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Moscoso, A., Heeman, F., Raghavan, S., Costoya-S\u00e1nchez, A., van Essen, M., Mainta, I., Camacho, V., Rodr\u00edguez-Fonseca, O., Silva-Rodr\u00edguez, J., Perissinotti, A., Gu, Y., Yun, J., Peretti, D., Ribaldi, F., Coomans, E. M., Brum, W. S., Grothe, M. J., Aguiar, P., Bischof, G. N., \u2026 Alzheimer\u2019s Disease Neuroimaging Initiative. (2025). Frequency and clinical outcomes&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3346"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3346\/revisions"}],"predecessor-version":[{"id":3441,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3346\/revisions\/3441"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3430"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}