{"id":3335,"date":"2025-11-14T16:53:43","date_gmt":"2025-11-14T21:53:43","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3335"},"modified":"2026-03-13T14:09:06","modified_gmt":"2026-03-13T18:09:06","slug":"longitudinal-functional-connectivity-during-rest-and-task-is-differentially-related-to-alzheimers-pathology-and-episodic-memory-in-older-adults-fischer-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/11\/14\/longitudinal-functional-connectivity-during-rest-and-task-is-differentially-related-to-alzheimers-pathology-and-episodic-memory-in-older-adults-fischer-et-al-2025\/","title":{"rendered":"Longitudinal functional connectivity during rest and task is differentially related to Alzheimer\u2019s pathology and episodic memory in older adults (Fischer et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3430\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png 300w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-150x150.png 150w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-12x12.png 12w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Fischer, L., Adams, J. N., Molloy, E. N., Tremblay-Mercier, J., Remz, J., Binette, A. P., Rajah, M. N., Villeneuve, S., Maass, A., &amp; PREVENT-AD Research Group. (2025). Longitudinal functional connectivity during rest and task is differentially related to alzheimer\u2019s pathology and episodic memory in older adults. <em>Scientific Reports<\/em>, <em>15<\/em>(38499). https:\/\/doi.org\/10.1038\/s41598-025-21596-0<br><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1038\/s41598-025-21596-0\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1038-s-41598-025-21596-0-span-style-color-var-ast-global-color-0-class-stk-highlight-longitudinal-functional-connectivity-during-rest-and-task-is-differentially-related-to-alzheimers-pathology-and-episodic-memory-in-older-adults-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1038\/s41598-025-21596-0\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Longitudinal functional connectivity during rest and task is differentially related to Alzheimer\u2019s pathology and episodic memory in older adults<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Larissa Fischer, Jenna N. Adams, E\u00f3in N. Molloy, Jennifer Tremblay-Mercier, Jordana Remz, Alexa Pichet Binette, M. Natasha Rajah, Sylvia Villeneuve, Anne Maass &amp; PREVENT-AD Research Group<\/strong><br><br>published in <em>Scientific Reports<\/em>, November 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Changes in functional connectivity (FC) strength involving the medial temporal lobe (MTL) and posteromedial cortex (PMC) are related to early Alzheimer\u2019s pathology and alterations in episodic memory performance in cognitively unimpaired older adults, but their dynamics remain unclear. We examined how longitudinal changes in FC involving MTL and PMC during resting-state, episodic memory encoding, and retrieval relate to subsequent amyloid- and tau-PET burden, longitudinal episodic memory performance, and the&nbsp;<em>APOE4<\/em>&nbsp;genotype in 152 cognitively unimpaired older adults from the PREVENT-AD cohort. We found&nbsp;<em>APOE4-<\/em>&nbsp;and fMRI paradigm-dependent associations of change in FC strength with pathology burden and change in episodic memory performance. Decreasing FC over time, or \u201chypoconnectivity\u201d, within PMC during rest in&nbsp;<em>APOE4<\/em>&nbsp;carriers and during retrieval in&nbsp;<em>APOE4<\/em>&nbsp;non-carriers was related to more amyloid and tau, respectively. Conversely, increasing FC over time, or \u201chyperconnectivity\u201d, within MTL during encoding in&nbsp;<em>APOE4<\/em>&nbsp;carriers and between MTL and PMC during retrieval independent of&nbsp;<em>APOE4<\/em>&nbsp;status was related to more tau. Further, increasing FC between MTL and PMC during rest, unlike during encoding, was beneficial for episodic memory. Our study highlights that pathology-related episodic memory network changes manifest differently during rest and task and have differential implications for episodic memory trajectories.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Fischer, L., Adams, J. N., Molloy, E. N., Tremblay-Mercier, J., Remz, J., Binette, A. P., Rajah, M. N., Villeneuve, S., Maass, A., &amp; PREVENT-AD Research Group. (2025). Longitudinal functional connectivity during rest and task is differentially related to alzheimer\u2019s pathology and episodic memory in older adults. Scientific Reports, 15(38499). https:\/\/doi.org\/10.1038\/s41598-025-21596-0 Full text : [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3430,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2.png",300,300,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/03\/Journal-Medical-Streamline-Bootstrap-2-12x12.png",12,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Fischer, L., Adams, J. N., Molloy, E. N., Tremblay-Mercier, J., Remz, J., Binette, A. P., Rajah, M. N., Villeneuve, S., Maass, A., &amp; PREVENT-AD Research Group. (2025). Longitudinal functional connectivity during rest and task is differentially related to alzheimer\u2019s pathology and episodic memory in older adults. Scientific Reports, 15(38499). https:\/\/doi.org\/10.1038\/s41598-025-21596-0 Full text :&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3335"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3335\/revisions"}],"predecessor-version":[{"id":3439,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3335\/revisions\/3439"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3430"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}