{"id":3302,"date":"2025-10-01T17:35:34","date_gmt":"2025-10-01T21:35:34","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3302"},"modified":"2025-10-01T17:35:34","modified_gmt":"2025-10-01T21:35:34","slug":"calibration-of-multisite-raters-for-prospective-visual-reads-of-amyloid-pet-scans-soleimani-meigooni-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/10\/01\/calibration-of-multisite-raters-for-prospective-visual-reads-of-amyloid-pet-scans-soleimani-meigooni-et-al-2025\/","title":{"rendered":"Calibration of Multisite Raters for Prospective Visual Reads of Amyloid PET Scans (Soleimani-Meigooni et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3298\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg\" width=\"761\" height=\"1000\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg 761w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_-228x300.jpg 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_-9x12.jpg 9w\" sizes=\"auto, (max-width: 761px) 100vw, 761px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Soleimani-Meigooni, D. N., Pezzoli, S., Blazhenets, G., La Joie, R., Lin, Z., Soppe, C. L., Johnson, D. R., Koran, M. E. I., McConathy, J. E., Nasrallah, I. M., Ponisio, M. R., Tanner, J. A., Villemagne, V. L., Windon, C. C., Zeineh, M., Biber, S., Kukull, W. A., O\u2019Connell, H., Peterson, D. J., \u2026 Alzheimer\u2019s Disease Neuroimaging Initiative. (2025). Calibration of multisite raters for prospective visual reads of amyloid PET scans. <em>Alzheimer\u2019s &amp; Dementia<\/em>, <em>21<\/em>(10). https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/alz.70732<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1002\/alz.70732\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1002-alz-70732-span-style-color-var-ast-global-color-0-class-stk-highlight-calibration-of-multisite-raters-for-prospective-visual-reads-of-amyloid-pet-scans-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1002\/alz.70732\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Calibration of Multisite Raters for Prospective Visual Reads of Amyloid PET Scans<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>David N. Soleimani-Meigooni*, Stefania Pezzoli*, Ganna Blazhenets, Renaud La Joie, Zoe Lin, Carol L. Soppe, Derek R. Johnson, Mary Ellen I. Koran, Jonathan E. McConathy, Ilya M. Nasrallah, Maria Rosana Ponisio, Jeremy A. Tanner, Victor L. Villemagne, Charles C. Windon, Michael Zeineh, Sarah Biber, Walter A. Kukull, Heather O&rsquo;Connell, Daniel J. Peterson, Elizabeth C. Mormino, Sterling C. Johnson, Gil D. Rabinovici, for the LEADS Consortium, The PREVENT-AD Research Group, Alzheimer&rsquo;s Disease Neuroimaging Initiative <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\">*Theses authors contributed equally. <\/span><\/em><br><br>published in <em>Alzheimer &amp; Dementia<\/em>, September 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Introduction:<\/strong> In multicenter Alzheimer&rsquo;s disease studies, amyloid positron emission tomography (PET) visual reads are typically performed centrally by a few experts. Incorporating a broader reader network enhances scalability and generalizability.<br><br><strong>Methods:<\/strong> Ten neuroimaging experts from eight Alzheimer&rsquo;s Disease Research Centers (ADRCs) visually read 180 amyloid PET scans (30 scans and 15 duplicate scans for each of four tracers, imaged across a wide variety of scanners), using preferred reading software without anatomical imaging or quantitation. Scans were classified as elevated or non-elevated per tracer-specific criteria. Inter- and intra-rater agreement was assessed.<br><br><strong>Results:<\/strong> Inter-rater agreement was substantial (Fleiss\u2019\u00a0<em>\u03ba<\/em>\u00a0=\u00a00.78), with full consensus on 69% of scans. Inter-rater reliability was substantial to perfect across tracers (Fleiss\u2019\u00a0<em>\u03ba<\/em>\u00a0=\u00a00.70\u20130.87). Intra-rater agreement was substantial to perfect (Cohen&rsquo;s\u00a0<em>\u03ba\u00a0<\/em>=\u00a00.79-1). Scans with intermediate (10\u201340 Centiloid) quantitation had lower reader agreement.<br><br><strong>Discussion:<\/strong> A multicenter expert network achieved substantial agreement classifying amyloid PET scans. These scans provide a standard for reader training and reliability assurance in future studies.<\/p><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Soleimani-Meigooni, D. N., Pezzoli, S., Blazhenets, G., La Joie, R., Lin, Z., Soppe, C. L., Johnson, D. R., Koran, M. E. I., McConathy, J. E., Nasrallah, I. M., Ponisio, M. R., Tanner, J. A., Villemagne, V. L., Windon, C. C., Zeineh, M., Biber, S., Kukull, W. A., O\u2019Connell, H., Peterson, D. J., \u2026 [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3298,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg",761,1000,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_-228x300.jpg",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg",761,1000,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg",761,1000,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg",761,1000,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_.jpg",761,1000,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/alz.v21.10.cover_-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Soleimani-Meigooni, D. N., Pezzoli, S., Blazhenets, G., La Joie, R., Lin, Z., Soppe, C. L., Johnson, D. R., Koran, M. E. I., McConathy, J. E., Nasrallah, I. M., Ponisio, M. R., Tanner, J. A., Villemagne, V. L., Windon, C. C., Zeineh, M., Biber, S., Kukull, W. A., O\u2019Connell, H., Peterson, D. J., \u2026&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3302"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3302\/revisions"}],"predecessor-version":[{"id":3303,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3302\/revisions\/3303"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3298"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}