{"id":3272,"date":"2025-09-19T16:26:41","date_gmt":"2025-09-19T20:26:41","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3272"},"modified":"2025-09-30T09:50:11","modified_gmt":"2025-09-30T13:50:11","slug":"amyloid-and-tau-pathology-in-cognitively-unimpaired-individuals-with-a-parental-history-of-alzheimer-disease-role-of-sex-and-parents-sex-ourry-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/09\/19\/amyloid-and-tau-pathology-in-cognitively-unimpaired-individuals-with-a-parental-history-of-alzheimer-disease-role-of-sex-and-parents-sex-ourry-et-al-2025\/","title":{"rendered":"Amyloid and Tau Pathology in Cognitively Unimpaired Individuals With a Parental History of Alzheimer Disease: Role of Sex and Parent&rsquo;s Sex (Ourry et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3273\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_.jpg\" width=\"825\" height=\"1088\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_.jpg 825w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-227x300.jpg 227w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-776x1024.jpg 776w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-768x1013.jpg 768w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-9x12.jpg 9w\" sizes=\"auto, (max-width: 825px) 100vw, 825px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Ourry, V., Fajardo-Valdez, A., Soucy, J.-P., Poirier, J., Breitner, J. C. S., Villeneuve, S., &amp; PREVENT-AD Research Group. (2025). Amyloid and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer disease: Role of sex and parent&rsquo;s sex. <em>Neurology<\/em>, <em>104<\/em>(9). https:\/\/doi.org\/10.1212\/wnl.0000000000213507<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1212\/wnl.0000000000213507\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1212-wnl-0000000000213507-span-style-color-var-ast-global-color-0-class-stk-highlight-amyloid-and-tau-pathology-in-cognitively-unimpaired-individuals-with-a-parental-history-of-alzheimer-disease-role-of-sex-and-parents-sex-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1212\/wnl.0000000000213507\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Amyloid and Tau Pathology in Cognitively Unimpaired Individuals with a Parental History of Alzheimer Disease: Role of Sex and Parent&rsquo;s Sex<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Valentin Ourry, Alfonso Fajardo-Valdez, Jean-Paul Soucy, Judes Poirier, John C.S. Breitner, and Sylvia Villeneuve for the PREVENT-AD Research Group<em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><\/strong><br>published in <em>Neurology<\/em>, April 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Background and Objectives:<\/strong> Female sex and a parental history of Alzheimer disease (AD), especially maternal, confer increased risk of AD. Associations between sex, or affected AD parent&rsquo;s sex, and biomarkers of AD are less clear. We examined whether sex or affected AD parent&rsquo;s sex influences (1) \u03b2-amyloid (A\u03b2) and tau burden\/accumulation, (2) the association between A\u03b2 and tau burden, and (3) brain and cognitive resilience to A\u03b2 and tau burden.<br><br><strong>Methods:<\/strong> The sample included 243 participants from the Presymptomatic Evaluation of Experimental or Novel Treatments for AD cohort in Canada. All participants with [18F]-NAV4694 and [18F]-AV1451 PET and MRI were included. We examined (1) sex or affected AD parent&rsquo;s sex differences on regional A\u03b2 and tau burden\/accumulation; (2) 2-way interactions between sex, or affected AD parent&rsquo;s sex, and A\u03b2 on tau burden; and (3) 3-way interactions between time, sex or affected AD parent&rsquo;s sex, and A\u03b2 or tau deposition on hippocampal volume (brain resilience) and cognition (cognitive resilience) over time.<br><br><strong>Results:<\/strong> Participants (69.4% female) were aged 68.3 \u00b1 5.1 years at their first PET scans. All were cognitively unimpaired at baseline. Longitudinal cognitive data were available for 242 participants (follow-up, 6.72 \u00b1 2.38 years), including 238 (6.53 \u00b1 2.48 years of follow-up) with MRI follow-ups and 115 (4.4 \u00b1 0.6 years of follow-up) with PET follow-ups, and 71 developed mild cognitive impairment. Women showed greater tau deposition (standardized \u03b2 = 0.13 \u00b1 0.3) and showed a stronger association between global A\u03b2 and tau deposition than men (standardized \u03b2 = 0.79 \u00b1 0.1). Individuals with an affected AD father showed stronger association between global A\u03b2 and tau deposition than those with an affected AD mother (standardized \u03b2 = 0.65 \u00b1 0.1). Women showed less A\u03b2-associated hippocampal atrophy over time (standardized \u03b2 = 0.24 \u00b1 0.1).<br><br><strong>Discussion:<\/strong> Women and, surprisingly, individuals with a paternal history of AD seemed more vulnerable to the A\u03b2-related spread of tau, whereas women showed greater brain resilience to A\u03b2. Understanding sex-specific risk and resilience could allow more clinical trial precision and personalization. A major limitation included the reduced sample for the affected AD parent&rsquo;s sex analyses.<\/p><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><br><\/p>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Ourry, V., Fajardo-Valdez, A., Soucy, J.-P., Poirier, J., Breitner, J. C. S., Villeneuve, S., &amp; PREVENT-AD Research Group. (2025). Amyloid and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer disease: Role of sex and parent&rsquo;s sex. Neurology, 104(9). https:\/\/doi.org\/10.1212\/wnl.0000000000213507 Full text : Here Amyloid and Tau Pathology in Cognitively [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3272","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_.jpg",825,1088,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-227x300.jpg",227,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-768x1013.jpg",768,1013,true],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-776x1024.jpg",776,1024,true],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_.jpg",825,1088,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_.jpg",825,1088,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/wnl.2025.104.issue-9.cover_-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":1,"uagb_excerpt":"Citation : Ourry, V., Fajardo-Valdez, A., Soucy, J.-P., Poirier, J., Breitner, J. C. S., Villeneuve, S., &amp; PREVENT-AD Research Group. (2025). Amyloid and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer disease: Role of sex and parent&rsquo;s sex. Neurology, 104(9). https:\/\/doi.org\/10.1212\/wnl.0000000000213507 Full text : Here Amyloid and Tau Pathology in Cognitively&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3272"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3272\/revisions"}],"predecessor-version":[{"id":3275,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3272\/revisions\/3275"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3273"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}