{"id":3267,"date":"2025-09-19T15:57:00","date_gmt":"2025-09-19T19:57:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3267"},"modified":"2025-09-30T09:50:06","modified_gmt":"2025-09-30T13:50:06","slug":"longitudinal-relationships-among-cerebrospinal-fluid-biomarkers-cerebral-blood-flow-and-grey-matter-volume-in-individuals-with-a-familial-history-of-alzheimers-disease-sanami-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/09\/19\/longitudinal-relationships-among-cerebrospinal-fluid-biomarkers-cerebral-blood-flow-and-grey-matter-volume-in-individuals-with-a-familial-history-of-alzheimers-disease-sanami-et-al-2025\/","title":{"rendered":"Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer&rsquo;s disease (Sanami et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3220\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg\" width=\"576\" height=\"768\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg 576w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg 225w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg 9w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Sanami, S., Intzandt, B., Huck, J., Villeneuve, S., Iturria-Medina, Y., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer&rsquo;s disease.\u00a0<em>Neurobiology of aging<\/em>,\u00a0<em>152<\/em>, 43\u201353. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.04.011<br><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.04.011\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1093-braincomms-fcae-031-span-style-color-var-ast-global-color-0-class-stk-highlight-longitudinal-relationships-among-cerebrospinal-fluid-biomarkers-cerebral-blood-flow-and-grey-matter-volume-in-individuals-with-a-amilial-history-of-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.04.011\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Longitudinal Relationships Among Cerebrospinal Fluid Biomarkers, Cerebral Blood Flow, and Grey Matter Volume in Individuals with a Familial History of Alzheimer&rsquo;s Disease<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Safa\u00a0Sanami,\u00a0Brittany\u00a0Intzandt,\u00a0Julia\u00a0Huck,\u00a0Sylvia\u00a0Villeneuve,\u00a0Yasser\u00a0Iturria-Medina,\u00a0Claudine J.\u00a0Gauthier,\u00a0PREVENT-AD Research Group<\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Neurobiology of Aging<\/em>, August 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Alzheimer\u2019s disease (AD) is a complex disease that involves complex interactions between protein biomarkers such as amyloid beta (A\u03b2) and tau, neurodegeneration, cerebrovascular health and inflammation. However, how these factors interact, especially in the early phases of disease development remain unclear. To address this, this study analyzed four-year longitudinal data from 110 cognitively unimpaired older adults with a family history of AD in the PreventAD cohort. We investigated relationships between CSF A\u03b2, 181-phosphorylated tau (p-tau), interleukin-8 (IL-8), cerebral blood flow (CBF), and grey matter volume (GMV) in groups with high and low cardiovascular risk levels. Longitudinally, lower CSF A\u03b2 within participants (a proxy for higher brain amyloid) was linked to a slower decline in regional CBF, particularly in those with higher cardiovascular risk. Similarly, in the high vascular risk group, higher IL-8 at baseline was associated with greater decline in CBF in the right superior temporal gyrus. Further, lower baseline CBF was associated with greater CSF p-tau accumulation over time. Finally, higher baseline CSF p-tau was associated with faster GM atrophy over 4 years, particularly in the hippocampus. Our results highlight the complex interactions between CSF misfolded proteins, inflammatory markers, and brain regional CBF and atrophy, and how these effects are more pronounced in individuals with higher vascular risk factor load. These findings demonstrate the need for comprehensive models of AD pathophysiology that integrate vascular health and inflammation measures alongside traditional biomarkers.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Sanami, S., Intzandt, B., Huck, J., Villeneuve, S., Iturria-Medina, Y., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer&rsquo;s disease.\u00a0Neurobiology of aging,\u00a0152, 43\u201353. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.04.011 Full text : Here Longitudinal Relationships Among Cerebrospinal Fluid [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg",225,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Sanami, S., Intzandt, B., Huck, J., Villeneuve, S., Iturria-Medina, Y., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer&rsquo;s disease.\u00a0Neurobiology of aging,\u00a0152, 43\u201353. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.04.011 Full text : Here Longitudinal Relationships Among Cerebrospinal Fluid&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3267"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3267\/revisions"}],"predecessor-version":[{"id":3268,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3267\/revisions\/3268"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3220"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}