{"id":3257,"date":"2025-09-19T15:02:49","date_gmt":"2025-09-19T19:02:49","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3257"},"modified":"2025-09-30T09:49:56","modified_gmt":"2025-09-30T13:49:56","slug":"plasma-p-tau217-and-tau-pet-predict-future-cognitive-decline-among-cognitively-unimpaired-individuals-implications-for-clinical-trials-ossenkoppele-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/09\/19\/plasma-p-tau217-and-tau-pet-predict-future-cognitive-decline-among-cognitively-unimpaired-individuals-implications-for-clinical-trials-ossenkoppele-et-al-2025\/","title":{"rendered":"Plasma p-Tau217 and Tau-PET Predict Future Cognitive Decline Among Cognitively Unimpaired Individuals: Implications for Clinical Trials (Ossenkoppele et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3258\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg\" width=\"440\" height=\"584\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg 440w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5-226x300.jpg 226w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5-9x12.jpg 9w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Ossenkoppele, R., Salvad\u00f3, G., Janelidze, S., Pichet Binette, A., Bali, D., Karlsson, L., Palmqvist, S., Mattsson-Carlgren, N., Stomrud, E., Therriault, J., Rahmouni, N., Rosa-Neto, P., Coomans, E. M., van de Giessen, E., van der Flier, W. M., Teunissen, C. E., Jonaitis, E. M., Johnson, S. C., Villeneuve, S., \u2026 Hansson, O. (2025). Plasma P-tau217 and tau-pet predict future cognitive decline among cognitively unimpaired individuals: Implications for clinical trials. <em>Nature Aging<\/em>, <em>5<\/em>(5), 883\u2013896. https:\/\/doi.org\/10.1038\/s43587-025-00835-z<br><\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1038\/s43587-025-00835-z\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1038-s-43587-025-00835-z-span-style-color-var-ast-global-color-0-class-stk-highlight-plasma-p-tau-217-and-tau-pet-predict-future-cognitive-decline-among-cognitively-nimpaired-individuals-implications-for-clinical-trials-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1038\/s43587-025-00835-z\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Plasma p-Tau217 and Tau-PET Predict Future Cognitive Decline Among Cognitively Unimpaired Individuals: Implications for Clinical Trials<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Rik Ossenkoppele, Gemma Salvad\u00f3, Shorena Janelidze, Alexa Pichet Binette, Divya Bali, Linda Karlsson, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Joseph Therriault, Nesrine Rahmouni, Pedro Rosa-Neto, Emma M. Coomans, Elsmarieke van de Giessen, Wiesje M. van der Flier, Charlotte E. Teunissen, Erin M. Jonaitis, Sterling C. Johnson, Sylvia Villeneuve, PREVENT-AD Research Group, Tammie L. S. Benzinger, Suzanne E. Schindler, Randall J. Bateman, James D. Doecke, Vincent Dor\u00e9, Azadeh Feizpour, Colin L. Masters, Christopher Rowe, Heather J. Wiste, Ronald C. Petersen, Clifford R. Jack Jr. &amp; Oskar Hansson<em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><\/strong><br><br>published in <em>Nature Aging<\/em>, March 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer\u2019s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal display similar associations with cognitive decline on a global cognitive composite test (R2PET\u2009=\u20090.34 versus R2plasma\u2009=\u20090.33, Pdifference\u2009=\u20090.653) and with progression to mild cognitive impairment (hazard ratio (HR)PET\u2009=\u20091.61 (1.48\u20131.76) versus HRplasma\u2009=\u20091.57 (1.43\u20131.72), Pdifference\u2009=\u20090.322). Combined plasma and PET models were superior to the single-biomarker models (R2\u2009=\u20090.35, P\u2009&lt;\u20090.01). Sequential selection using plasma phosphorylated tau at threonine 217 (p-tau217) and then tau-PET reduced the number of participants required for a clinical trial by 94%, compared to a 76% reduction when using plasma p-tau217 alone. Thus, plasma p-tau217 and tau-PET showed similar performance for predicting future cognitive decline in CU individuals, and their sequential use enhances screening efficiency for preclinical AD trials.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Ossenkoppele, R., Salvad\u00f3, G., Janelidze, S., Pichet Binette, A., Bali, D., Karlsson, L., Palmqvist, S., Mattsson-Carlgren, N., Stomrud, E., Therriault, J., Rahmouni, N., Rosa-Neto, P., Coomans, E. M., van de Giessen, E., van der Flier, W. M., Teunissen, C. E., Jonaitis, E. M., Johnson, S. C., Villeneuve, S., \u2026 Hansson, O. (2025). Plasma [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3258,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg",440,584,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5-226x300.jpg",226,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg",440,584,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg",440,584,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg",440,584,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5.jpg",440,584,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/5-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Ossenkoppele, R., Salvad\u00f3, G., Janelidze, S., Pichet Binette, A., Bali, D., Karlsson, L., Palmqvist, S., Mattsson-Carlgren, N., Stomrud, E., Therriault, J., Rahmouni, N., Rosa-Neto, P., Coomans, E. M., van de Giessen, E., van der Flier, W. M., Teunissen, C. E., Jonaitis, E. M., Johnson, S. C., Villeneuve, S., \u2026 Hansson, O. (2025). Plasma&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3257"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3257\/revisions"}],"predecessor-version":[{"id":3263,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3257\/revisions\/3263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3258"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}