{"id":3254,"date":"2025-09-18T15:54:51","date_gmt":"2025-09-18T19:54:51","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3254"},"modified":"2025-09-30T09:49:50","modified_gmt":"2025-09-30T13:49:50","slug":"tau-pet-positivity-in-individuals-with-and-without-cognitive-impairment-varies-with-age-amyloid-%ce%b2-status-apoe-genotype-and-sex-ossenkoppele-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/09\/18\/tau-pet-positivity-in-individuals-with-and-without-cognitive-impairment-varies-with-age-amyloid-%ce%b2-status-apoe-genotype-and-sex-ossenkoppele-et-al-2025\/","title":{"rendered":"Tau PET Positivity in Individuals With and Without Cognitive Impairment Varies with Age, Amyloid-\u03b2 Status, APOE Genotype and Sex (Ossenkoppele et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3255\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png\" width=\"440\" height=\"584\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png 440w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8-226x300.png 226w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8-9x12.png 9w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Ossenkoppele, R., Coomans, E. M., Apostolova, L. G., Baker, S. L., Barthel, H., Beach, T. G., Benzinger, T. L., Betthauser, T., Bischof, G. N., Bottlaender, M., Bourgeat, P., den Braber, A., Brendel, M., Brickman, A. M., Cash, D. M., Carrillo, M. C., Coath, W., Christian, B. T., Dickerson, B. C., \u2026 Hansson, O. (2025). Tau Pet positivity in individuals with and without cognitive impairment varies with age, amyloid-\u03b2 status, APOE genotype and sex. <em>Nature Neuroscience, 28<\/em>(8), 1610\u20131621. https:\/\/doi.org\/10.1038\/s41593-025-02000-6<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1038\/s41593-025-02000-6\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1038-s-41593-025-02000-6-span-style-color-var-ast-global-color-0-class-stk-highlight-tau-pet-positivity-in-individuals-with-and-without-cognitive-impairment-varies-with-age-amyloid-\u03b2-status-apoe-genotype-and-sex-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1038\/s41593-025-02000-6\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Tau PET Positivity in Individuals With and Without Cognitive Impairment Varies with Age, Amyloid-\u03b2 Status, APOE Genotype and Sex<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Rik Ossenkoppele, Emma M. Coomans, Liana G. Apostolova, Suzanne L. Baker, Henryk Barthel, Thomas G. Beach, Tammy L. S. Benzinger, Tobey Betthauser, G\u00e9rard N. Bischof, Michel Bottlaender, Pierick Bourgeat, Anouk den Braber, Matthias Brendel, Adam M. Brickman, David M. Cash, Maria C. Carrillo, William Coath, Bradley T. Christian, Brad C. Dickerson, Vincent Dore, Alexander Drzezga, Azadeh Feizpour, Wiesje M. van der Flier, Nicolai Franzmeier, Giovanni B. Frisoni, Valentina Garibotto, Elsmarieke van de Giessen, Juan Domingo-Gispert, Johannes Gnoerich, Yuna Gu, Yihui Guan, Bernard J. Hanseeuw, Theresa M. Harrison, Clifford R. Jack, Elena Jaeger, William J. Jagust, Willemijn J. Jansen, Renaud La Joie, Keith A. Johnson, Sterling C. Johnson, Ian A. Kennedy, Jun Pyo Kim, Koen van Laere, Julien Lagarde, Patrick Lao, Jos\u00e9 A. Luchsinger, Silke Kern, William C. Kreisl, Vincent Malotaux, Maura Malpetti, Jennifer J. Manly, Xiaoxie Mao, Niklas Mattsson-Carlgren, Mayo Clinic Study on Aging, Konstantin Messerschmidt, Carolina Minguillon, Elizabeth M. Mormino, John T. O\u2019Brien, Sebastian Palmqvist, Debora E. Peretti, Ron C. Petersen, Yolande A. L. Pijnenburg, Michael J. Pontecorvo, Judes Poirier, PREVENT-AD Research Group, Gil D. Rabinovici, Nesrine Rahmouni, Shannon L. Risacher, Pedro Rosa-Neto, Howard Rosen, Christopher C. Rowe, James B. Rowe, Michael Rullmann, Yasmine Salman, Marie Sarazin, Andrew J. Saykin, Julie A. Schneider, Michael Sch\u00f6ll, Jonathan M. Schott, Sang Won Seo, Geidy E. Serrano, Sergey Shcherbinin, Mahnaz Shekari, Ingmar Skoog, Ruben Smith, Reisa A. Sperling, Laure Spruyt, Erik Stomrud, Olof Strandberg, Joseph Therriault, Fang Xie, Rik Vandenberghe, Victor L. Villemagne, Sylvia Villeneuve, Pieter Jelle Visser, Hillary Vossler, Christina B. Young, Colin Groot &amp; Oskar Hansson<\/strong><br><br>published in <em>Nature Neuroscience<\/em>, July 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer\u2019s disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N\u2009=\u200912,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60\u2009years to 80\u2009years, tau PET positivity in a temporal composite region increased from 1.1% to 4.4% among CU amyloid-\u03b2 (A\u03b2)-negative participants and from 17.4% to 22.2% among CU A\u03b2-positive participants. Across the same age span, tau PET positivity decreased from 68.0% to 52.9% in participants with MCI and from 91.5% to 74.6% in participants with dementia. Age, A\u03b2 status, APOE \u03b54 carriership and female sex were all associated with a higher prevalence of tau PET positivity across groups. APOE \u03b54 carriership in CU individuals lowered the age at onset of both A\u03b2 positivity and tau positivity by decades. Finally, we replicated these associations in an independent autopsy dataset (N\u2009=\u20095,072 from 3 cohorts).<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Ossenkoppele, R., Coomans, E. M., Apostolova, L. G., Baker, S. L., Barthel, H., Beach, T. G., Benzinger, T. L., Betthauser, T., Bischof, G. N., Bottlaender, M., Bourgeat, P., den Braber, A., Brendel, M., Brickman, A. M., Cash, D. M., Carrillo, M. C., Coath, W., Christian, B. T., Dickerson, B. C., \u2026 Hansson, O. [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3255,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png",440,584,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8-226x300.png",226,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png",440,584,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png",440,584,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png",440,584,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8.png",440,584,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/8-9x12.png",9,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Ossenkoppele, R., Coomans, E. M., Apostolova, L. G., Baker, S. L., Barthel, H., Beach, T. G., Benzinger, T. L., Betthauser, T., Bischof, G. N., Bottlaender, M., Bourgeat, P., den Braber, A., Brendel, M., Brickman, A. M., Cash, D. M., Carrillo, M. C., Coath, W., Christian, B. T., Dickerson, B. C., \u2026 Hansson, O.&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3254"}],"version-history":[{"count":1,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3254\/revisions"}],"predecessor-version":[{"id":3256,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3254\/revisions\/3256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3255"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}