{"id":3236,"date":"2025-09-16T14:25:35","date_gmt":"2025-09-16T18:25:35","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3236"},"modified":"2025-09-30T09:49:39","modified_gmt":"2025-09-30T13:49:39","slug":"brain-and-csf-alzheimers-biomarkers-are-associated-with-serpine1-gene-expression-picard-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/09\/16\/brain-and-csf-alzheimers-biomarkers-are-associated-with-serpine1-gene-expression-picard-et-al-2025\/","title":{"rendered":"Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression (Picard et al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><style>.stk-3a7774a .stk-img-wrapper{width:240px !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3259\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png\" width=\"240\" height=\"345\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png 240w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7-209x300.png 209w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7-8x12.png 8w\" sizes=\"auto, (max-width: 240px) 100vw, 240px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Picard, C., Zetterberg, H., Blennow, K., Villeneuve, S., Poirier, J., &amp; on behalf of the PREVENT-AD Research Group. (2025). Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression. <em>Genes, 16<\/em>(7), 818. https:\/\/doi.org\/10.3390\/genes16070818<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.3390\/genes16070818\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-3390-genes-16070818-span-style-color-var-ast-global-color-0-class-stk-highlight-brain-and-csf-alzheimers-biomarkers-are-associated-with-serpine-1-gene-expression-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.3390\/genes16070818\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Cynthia Picard, Henrik Zetterberg, Kaj Blennow, Sylvia Villeneuve, Judes Poirier, on behalf of the PREVENT-AD Research Group<\/strong><br><br>published in <em>Genes<\/em>, July 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Background: SERPINE1, also known as plasminogen activator inhibitor (PAI), has been proposed as a potential blood biomarker for the early detection and diagnosis of Alzheimer\u2019s disease (AD). Expanding on previous studies, this research contrasted SERPINE1 levels in CSF and brain tissue of AD patients and those at risk for AD with established AD biomarkers. Methods: Utilizing OLINK and immunoassay methods, CSF SERPINE1 protein levels were quantified across two separate cohorts: PREVENT-AD and ADNI. Microarray and RNAseq were used to measure tissue SERPINE1 mRNA levels in two separate cohorts: the Douglas-Bell Canada Brain Bank and the Mayo Clinic Brain Bank. Results: At the pre-clinical stage, elevated CSF levels of pTau, tTau and synaptic markers, alongside reduced hippocampal volume, correlate with CSF SERPINE1 levels. Elevated cortical SERPINE1 mRNA levels in autopsy-confirmed AD show weak correlation with regional plaques and tangles densities, but strong correlation with Braak staging. Conclusions: CSF SERPINE1 levels can be used as an early biomarker for the detection of pathological changes associated with AD. Higher SERPINE1 levels correlate more strongly with tau pathology than with amyloid formation or deposition.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Picard, C., Zetterberg, H., Blennow, K., Villeneuve, S., Poirier, J., &amp; on behalf of the PREVENT-AD Research Group. (2025). Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression. Genes, 16(7), 818. https:\/\/doi.org\/10.3390\/genes16070818 Full text : Here Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression Cynthia Picard, Henrik Zetterberg, [&hellip;]<\/p>","protected":false},"author":6,"featured_media":3259,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png",240,345,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7-209x300.png",209,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png",240,345,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png",240,345,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png",240,345,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7.png",240,345,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/09\/cover-genes-v16-i7-8x12.png",8,12,true]},"uagb_author_info":{"display_name":"Nolan-Patrick Cunningham","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/nolan-patrick-cunningham\/"},"uagb_comment_info":2,"uagb_excerpt":"Citation : Picard, C., Zetterberg, H., Blennow, K., Villeneuve, S., Poirier, J., &amp; on behalf of the PREVENT-AD Research Group. (2025). Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression. Genes, 16(7), 818. https:\/\/doi.org\/10.3390\/genes16070818 Full text : Here Brain and CSF Alzheimer\u2019s Biomarkers Are Associated with SERPINE1 Gene Expression Cynthia Picard, Henrik Zetterberg,&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3236"}],"version-history":[{"count":4,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3236\/revisions"}],"predecessor-version":[{"id":3270,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3236\/revisions\/3270"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3259"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}