{"id":3162,"date":"2025-06-01T14:42:00","date_gmt":"2025-06-01T18:42:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3162"},"modified":"2025-09-16T14:58:37","modified_gmt":"2025-09-16T18:58:37","slug":"sex-and-apoe4-specific-links-between-cardiometabolic-risk-factors-and-white-matter-alterations-in-individuals-with-a-family-history-of-alzheimers-disease-tremblay-sa-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/06\/01\/sex-and-apoe4-specific-links-between-cardiometabolic-risk-factors-and-white-matter-alterations-in-individuals-with-a-family-history-of-alzheimers-disease-tremblay-sa-et-al-2025\/","title":{"rendered":"Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer\u2019s disease. (Tremblay SA. et Al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3220\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg\" width=\"576\" height=\"768\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg 576w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg 225w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg 9w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Tremblay, S. A., Nathan Spreng, R., Wearn, A., Alasmar, Z., Pirhadi, A., Tardif, C. L., Chakravarty, M. M., Villeneuve, S., Leppert, I. R., Carbonell, F., Medina, Y. I., Steele, C. J., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer&rsquo;s disease. <em>Neurobiology of aging<\/em>, <em>150<\/em>, 80\u201396. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.03.003<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0197458025000429?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1016-j-neurobiolaging-2025-03-003-span-style-color-var-ast-global-color-0-class-stk-highlight-sex-and-apoe-4-specific-links-between-cardiometabolic-risk-factors-and-white-matter-alterations-in-individuals-with-a-family-history-of-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2025.03.003\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer\u2019s disease.<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Tremblay, S. A., Nathan Spreng, R., Wearn, A., Alasmar, Z., Pirhadi, A., Tardif, C. L., Chakravarty, M. M., Villeneuve, S., Leppert, I. R., Carbonell, F., Medina, Y. I., Steele, C. J., Gauthier, C. J., &amp; PREVENT-AD Research Group<\/strong><br><br>published in <em>Neurobiology of Aging<\/em>, June 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Early detection of pathological changes in Alzheimer&rsquo;s disease (AD) has garnered significant attention in the last few decades as interventions aiming to prevent progression will likely be most effective when initiated early. White matter (WM) alterations are among the earliest changes in AD, yet limited work has comprehensively characterized the effects of AD risk factors on WM. In older adults with a family history of AD, we investigated the sex-specific and APOE genotype-related relationships between WM microstructure and risk factors. Multiple MRI-derived metrics were integrated using a multivariate approach based on the Mahalanobis distance (D2). To uncover the specific biological underpinnings of these WM alterations, we then extracted the contribution of each MRI feature to D2 in significant clusters. Lastly, the links between WM D2 and cognition were explored. WM D2 in several regions was associated with high systolic blood pressure, BMI, and glycated hemoglobin, and low cholesterol, in both males and females. APOE4 + displayed a distinct risk pattern, with LDL-cholesterol having a detrimental effect only in carriers, and this pattern was linked to immediate memory performance. Myelination was the main mechanism underlying WM alterations. Our findings reveal that combined exposure to multiple cardiometabolic risk factors negatively impacts microstructural health, which may subsequently affect cognition. Notably, APOE4 carriers exhibited a different risk pattern, especially in the role of LDL, suggesting distinct underlying mechanisms in this group.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Tremblay, S. A., Nathan Spreng, R., Wearn, A., Alasmar, Z., Pirhadi, A., Tardif, C. L., Chakravarty, M. M., Villeneuve, S., Leppert, I. R., Carbonell, F., Medina, Y. I., Steele, C. J., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals [&hellip;]<\/p>","protected":false},"author":2,"featured_media":3220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-225x300.jpg",225,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580.jpg",576,768,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/05\/X01974580-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Tremblay, S. A., Nathan Spreng, R., Wearn, A., Alasmar, Z., Pirhadi, A., Tardif, C. L., Chakravarty, M. M., Villeneuve, S., Leppert, I. R., Carbonell, F., Medina, Y. I., Steele, C. J., Gauthier, C. J., &amp; PREVENT-AD Research Group (2025). Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3162"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3162\/revisions"}],"predecessor-version":[{"id":3230,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3162\/revisions\/3230"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3220"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}