{"id":3153,"date":"2025-02-05T13:59:00","date_gmt":"2025-02-05T18:59:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3153"},"modified":"2025-09-16T13:32:28","modified_gmt":"2025-09-16T17:32:28","slug":"plasma-p-tau217-identifies-cognitively-normal-older-adults-who-will-develop-cognitive-impairment-in-a-10-year-window-yakoub-y-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/02\/05\/plasma-p-tau217-identifies-cognitively-normal-older-adults-who-will-develop-cognitive-impairment-in-a-10-year-window-yakoub-y-et-al-2025\/","title":{"rendered":"Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window. (Yakoub Y. et Al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3154\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp\" width=\"650\" height=\"855\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp 650w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025-228x300.webp 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025-9x12.webp 9w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Yakoub, Y., Gonzalez-Ortiz, F., Ashton, N. J., D\u00e9ry, C., Strikwerda-Brown, C., St-Onge, F., Ourry, V., Sch\u00f6ll, M., Geddes, M. R., Ducharme, S., Montembeault, M., Rosa-Neto, P., Soucy, J. P., Breitner, J. C. S., Zetterberg, H., Blennow, K., Poirier, J., Villeneuve, S., &amp; PREVENT\u2212AD Research Group (2025). Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window. <em>Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association<\/em>, <em>21<\/em>(2), e14537. https:\/\/doi.org\/10.1002\/alz.14537<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14537\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-alz-journals-onlinelibrary-wiley-com-doi-10-1002-alz-14537-span-style-color-var-ast-global-color-0-class-stk-highlight-plasma-p-tau-217-identifies-cognitively-normal-older-adults-who-will-develop-cognitive-impairment-in-a-10-year-window-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14537\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window.<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Yakoub, Y., Gonzalez-Ortiz, F., Ashton, N. J., D\u00e9ry, C., Strikwerda-Brown, C., St-Onge, F., Ourry, V., Sch\u00f6ll, M., Geddes, M. R., Ducharme, S., Montembeault, M., Rosa-Neto, P., Soucy, J. P., Breitner, J. C. S., Zetterberg, H., Blennow, K., Poirier, J., Villeneuve, S., &amp; PREVENT\u2212AD Research Group<\/strong>.<strong> <\/strong><br><br>published in <em>Alzheimer&rsquo;s &amp; Dementia<\/em>, February 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><br><strong>Introduction:<\/strong> We assessed the prognostic accuracy of plasma p-tau217 in predicting the progression to mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals over a mean follow-up of 5.65 years after plasma collection (range 1.01-10.47).<br><br><strong>Methods:<\/strong> We included 215 participants from the PREVENT-AD cohort with plasma A\u03b2<sub>42\/40<\/sub> and p-tau217, 159 with cerebrospinal fluid (CSF) A\u03b2<sub>42\/40<\/sub> and p-tau217, and 155 with <sup>18<\/sup>F-NAV4694 and <sup>18<\/sup>F-flortaucipir PET scans. MCI progression was determined by multidisciplinary consensus among memory experts blind to biomarker and genetic information.<br><br><strong>Results:<\/strong> Cox proportional hazard models indicated a greater progression rate in A+T+<sub>plasma<\/sub> and A-T+<sub>plasma<\/sub> compared to A-T-<sub>plasma<\/sub> individuals (HR = 7.81 [95% CI = 3.92 to 15.59] and HR = 4.25 [1.60-11.31] respectively). Similar results were found with CSF (HR = 3.63 [1.72-7.70]) and PET (HR = 9.30 [3.67-23.55]).<br><br><strong>Discussion:<\/strong> Plasma p-tau217 is a prognostic marker for identifying individuals who will develop cognitive impairment within ten years.<br><br><strong>Highlights:<\/strong> Elevated plasma p-tau217 levels in CU individuals indicate future clinical progression. Adding plasma A\u03b2<sub>42\/40<\/sub> status to p-tau markers did not improve the prediction to MCI. All individuals with abnormal tau PET measured in a temporal meta-ROI progressed to MCI.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Yakoub, Y., Gonzalez-Ortiz, F., Ashton, N. J., D\u00e9ry, C., Strikwerda-Brown, C., St-Onge, F., Ourry, V., Sch\u00f6ll, M., Geddes, M. R., Ducharme, S., Montembeault, M., Rosa-Neto, P., Soucy, J. P., Breitner, J. C. S., Zetterberg, H., Blennow, K., Poirier, J., Villeneuve, S., &amp; PREVENT\u2212AD Research Group (2025). Plasma p-tau217 identifies cognitively normal older adults [&hellip;]<\/p>","protected":false},"author":2,"featured_media":3154,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp",650,855,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025-150x150.webp",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025-228x300.webp",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp",650,855,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp",650,855,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp",650,855,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025.webp",650,855,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Alz-2025-9x12.webp",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Yakoub, Y., Gonzalez-Ortiz, F., Ashton, N. J., D\u00e9ry, C., Strikwerda-Brown, C., St-Onge, F., Ourry, V., Sch\u00f6ll, M., Geddes, M. R., Ducharme, S., Montembeault, M., Rosa-Neto, P., Soucy, J. P., Breitner, J. C. S., Zetterberg, H., Blennow, K., Poirier, J., Villeneuve, S., &amp; PREVENT\u2212AD Research Group (2025). Plasma p-tau217 identifies cognitively normal older adults&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3153"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3153\/revisions"}],"predecessor-version":[{"id":3233,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3153\/revisions\/3233"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3154"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}