{"id":3139,"date":"2025-01-18T10:25:00","date_gmt":"2025-01-18T15:25:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=3139"},"modified":"2025-09-16T13:36:34","modified_gmt":"2025-09-16T17:36:34","slug":"novel-synaptic-markers-predict-early-tau-pathology-and-cognitive-deficit-in-an-asymptomatic-population-at-risk-of-alzheimers-disease-ao-j-et-al-2025","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2025\/01\/18\/novel-synaptic-markers-predict-early-tau-pathology-and-cognitive-deficit-in-an-asymptomatic-population-at-risk-of-alzheimers-disease-ao-j-et-al-2025\/","title":{"rendered":"Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer\u2019s disease. (Ao J. et Al., 2025)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-3140\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png\" width=\"440\" height=\"585\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png 440w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025-226x300.png 226w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025-9x12.png 9w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Ao, J., Picard, C., Auld, D., Zetterberg, H., Brinkmalm, A., Blennow, K., Villeneuve, S., Breitner, J. C. S., Poirier, J., &amp; PREVENT-AD research group (2025). Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer&rsquo;s disease. <em>Molecular psychiatry<\/em>, 10.1038\/s41380-024-02884-z. Advance online publication. https:\/\/doi.org\/10.1038\/s41380-024-02884-z<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02884-z\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-www-nature-com-articles-s-41380-024-02884-z-span-style-color-var-ast-global-color-0-class-stk-highlight-novel-synaptic-markers-predict-early-tau-pathology-and-cognitive-deficit-in-an-asymptomatic-population-at-risk-of-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02884-z\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer\u2019s disease. <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Ao, J., Picard, C., Auld, D., Zetterberg, H., Brinkmalm, A., Blennow, K., Villeneuve, S., Breitner, J. C. S., Poirier, J., &amp; PREVENT-AD research group<\/strong><br><br>published in <em>Molecular Psychiatry<\/em>, January 2025. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>Cognitive dysfunction in Alzheimer&rsquo;s disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Three of these (SYT1, SNAP25, and ADAM23) are derived from pre-synaptic structures, while ADAM22 reflects post-synaptic changes. All four markers correlated strongly with tau protein measures. In statistical models, SYT1 accounted for more than half the total variance in both total- and P(181)-tau levels. Observed correlations with CSF levels of Alzheimer amyloid-\u03b2 (A\u03b242) were somewhat weaker. In longitudinal data, baseline levels of ADAM22 and ADAM23 robustly predicted increase over time in both total- and P-tau. CSF SYT1 levels also correlated with PET image uptake of tau and (at a trend level) A\u03b2 in areas of interest for early AD pathology. CSF SYT1 and SNAP25 levels correlated inversely with a global psychometric score and several of its domain subscales. In quantitative trait loci analyses, all four synaptic markers were associated with at least one AD genetic risk locus. Upon \u00ab\u00a0staging\u00a0\u00bb participants by their evidence of amyloid and tau pathology (A\/T\/N framework), the CSF synaptic markers were unexpectedly reduced in participants with CSF evidence of amyloid but not tau pathology. They were clearly elevated, however, in the CSF of persons with indications of both tau and amyloid pathology. These observations provide evidence for clear pre-synaptic degeneration in cognitively unimpaired persons with biomarker evidence of early AD pathology.<br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Ao, J., Picard, C., Auld, D., Zetterberg, H., Brinkmalm, A., Blennow, K., Villeneuve, S., Breitner, J. C. S., Poirier, J., &amp; PREVENT-AD research group (2025). Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer&rsquo;s disease. Molecular psychiatry, 10.1038\/s41380-024-02884-z. Advance online publication. https:\/\/doi.org\/10.1038\/s41380-024-02884-z Full text [&hellip;]<\/p>","protected":false},"author":2,"featured_media":3140,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[20,9],"tags":[15],"class_list":["post-3139","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2025-2","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png",440,585,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025-150x150.png",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025-226x300.png",226,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png",440,585,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png",440,585,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png",440,585,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025.png",440,585,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2025\/04\/Molecular-Psychiatry-01-2025-9x12.png",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Ao, J., Picard, C., Auld, D., Zetterberg, H., Brinkmalm, A., Blennow, K., Villeneuve, S., Breitner, J. C. S., Poirier, J., &amp; PREVENT-AD research group (2025). Novel synaptic markers predict early tau pathology and cognitive deficit in an asymptomatic population at risk of Alzheimer&rsquo;s disease. Molecular psychiatry, 10.1038\/s41380-024-02884-z. Advance online publication. https:\/\/doi.org\/10.1038\/s41380-024-02884-z Full text&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3139","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=3139"}],"version-history":[{"count":2,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3139\/revisions"}],"predecessor-version":[{"id":3235,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/3139\/revisions\/3235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/3140"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=3139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=3139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=3139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}