{"id":2995,"date":"2024-11-27T16:44:00","date_gmt":"2024-11-27T21:44:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2995"},"modified":"2025-04-22T16:06:48","modified_gmt":"2025-04-22T20:06:48","slug":"synergistic-association-of-a%ce%b2-and-tau-pathology-with-cortical-neurophysiology-and-cognitive-decline-in-asymptomatic-older-adults","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/11\/27\/synergistic-association-of-a%ce%b2-and-tau-pathology-with-cortical-neurophysiology-and-cognitive-decline-in-asymptomatic-older-adults\/","title":{"rendered":"Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. (Weisman et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2997\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg\" width=\"440\" height=\"585\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg 440w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9-226x300.jpg 226w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9-9x12.jpg 9w\" sizes=\"auto, (max-width: 440px) 100vw, 440px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Gallego-Rudolf, J., Wiesman, A. I., Pichet Binette, A., Villeneuve, S., Baillet, S., &amp; PREVENT-AD Research Group (2024). Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. <em>Nature neuroscience<\/em>, <em>27<\/em>(11), 2130\u20132137. https:\/\/doi.org\/10.1038\/s41593-024-01763-8<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41593-024-01763-8\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-www-nature-com-articles-s-41593-024-01763-8-span-style-color-var-ast-global-color-0-class-stk-highlight-strong-synergistic-association-of-a\u03b2-and-tau-pathology-with-cortical-neurophysiology-and-cognitive-decline-in-asymptomatic-older-adults-strong-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/www.nature.com\/articles\/s41593-024-01763-8\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\"><strong>Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults<\/strong> <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Gallego-Rudolf J, Weisman A.I, Pichet Binette A, Villeneuve S, Baillet S, PREVENT-AD research group. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Nature Neuroscience<\/em>, November 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-5587e5c\" data-block-id=\"5587e5c\"><style>.stk-5587e5c .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-5587e5c .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>Animal and computational models of Alzheimer\u2019s disease (AD) indicate that early amyloid-\u03b2 (A\u03b2) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions manifest an opposite, suppressive effect as behavioral deficits emerge. Here we report analogous changes in macroscopic oscillatory neurophysiology in the human brain. We used positron emission tomography and task-free magnetoencephalography to test the effects of A\u03b2 and tau deposition on cortical neurophysiology in 104 cognitively unimpaired older adults with a family history of sporadic AD. In these asymptomatic individuals, we found that A\u03b2 depositions colocalize with accelerated neurophysiological activity. In those also presenting medial\u2013temporal tau pathology, linear mixed effects of A\u03b2 and tau depositions indicate a shift toward slower neurophysiological activity, which was also linked to cognitive decline. We conclude that early A\u03b2 and tau depositions relate synergistically to human cortical neurophysiology and subsequent cognitive decline. Our findings provide insight into the multifaceted neurophysiological mechanisms engaged in the preclinical phases of AD.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Gallego-Rudolf, J., Wiesman, A. I., Pichet Binette, A., Villeneuve, S., Baillet, S., &amp; PREVENT-AD Research Group (2024). Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. Nature neuroscience, 27(11), 2130\u20132137. https:\/\/doi.org\/10.1038\/s41593-024-01763-8 Full text : Here Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2997,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg",440,585,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9-226x300.jpg",226,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg",440,585,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg",440,585,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg",440,585,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9.jpg",440,585,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature-neuroscience-9-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Gallego-Rudolf, J., Wiesman, A. I., Pichet Binette, A., Villeneuve, S., Baillet, S., &amp; PREVENT-AD Research Group (2024). Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. Nature neuroscience, 27(11), 2130\u20132137. https:\/\/doi.org\/10.1038\/s41593-024-01763-8 Full text : Here Synergistic association of A\u03b2 and tau pathology with cortical neurophysiology&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=2995"}],"version-history":[{"count":5,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2995\/revisions"}],"predecessor-version":[{"id":3136,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2995\/revisions\/3136"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2997"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=2995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=2995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=2995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}