{"id":2981,"date":"2024-09-20T13:00:00","date_gmt":"2024-09-20T17:00:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2981"},"modified":"2025-04-22T09:45:10","modified_gmt":"2025-04-22T13:45:10","slug":"osteopontin-a-novel-marker-of-pre-symptomatic-sporadic-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/09\/20\/osteopontin-a-novel-marker-of-pre-symptomatic-sporadic-alzheimers-disease\/","title":{"rendered":"Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer&rsquo;s disease. (Quesnel et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2984\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg\" width=\"761\" height=\"1000\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg 761w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-228x300.jpg 228w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-9x12.jpg 9w\" sizes=\"auto, (max-width: 761px) 100vw, 761px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Quesnel, M. J., Labont\u00e9, A., Picard, C., Bowie, D. C., Zetterberg, H., Blennow, K., Brinkmalm, A., Villeneuve, S., Poirier, J., Alzheimer&rsquo;s Disease Neuroimaging Initiative, &amp; PREVENT\u2010AD Research Group (2024). Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer&rsquo;s disease. <em>Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association<\/em>, <em>20<\/em>(9), 6008\u20136031. https:\/\/doi.org\/10.1002\/alz.14065<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39072932\/\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-pubmed-ncbi-nlm-nih-gov-39072932-span-style-color-var-ast-global-color-0-class-stk-highlight-osteopontin-a-novel-marker-of-pre-symptomatic-sporadic-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39072932\/\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer&rsquo;s disease<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Quesnel M.J, Labont\u00e9 A, Picard C, Bowie D.C, Zetterberg H, Blennow K, Brinkmalm A, Villeneuve S, Poirier J,  Alzheimer\u2019s Disease Neuroimaging Initiative, PREVENT-AD research group.<\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Alzheimer&rsquo;s &amp; Dementia<\/em>, September 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b7c568c\" data-block-id=\"b7c568c\"><style>.stk-b7c568c .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-b7c568c .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>We investigate the role of osteopontin (OPN) in participants with Pre-symptomatic Alzheimer&rsquo;s disease (AD), mild cognitive impairment (MCI), and in AD brains. Cerebrospinal fluid (CSF) OPN, AD, and synaptic biomarker levels were measured in 109 cognitively unimpaired (CU), parental-history positive Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer&rsquo;s Disease (PREVENT-AD) participants, and in 167 CU and 399 participants with MCI from the Alzheimer&rsquo;s Disease Neuroimaging Initiative (ADNI) cohort. OPN levels were examined as a function of amyloid beta (A\u03b2) and tau positivity. Survival analyses investigated the link between OPN and rate of conversion to AD. In PREVENT-AD, CSF OPN was positively correlated with synaptic biomarkers. In PREVENT-AD and ADNI, OPN was elevated in CSF A\u03b242\/40(+)\/total tau(+) and CSF A\u03b242\/40(+)\/phosphorylated tau181(+) individuals. In ADNI, OPN was increased in A\u03b2(+) positron emission tomography (PET) and tau(+) PET individuals, and associated with an accelerated rate of conversion to AD. OPN was elevated in autopsy-confirmed AD brains. Strong associations between CSF OPN and key markers of AD pathophysiology suggest a significant role for OPN in tau neurobiology, particularly in the early stages of the disease. In the Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer&rsquo;s Disease cohort, we discovered that cerebrospinal fluid (CSF) osteopontin (OPN) levels can indicate early synaptic dysfunction, tau deposition, and neuronal loss in cognitively unimpaired elderly with a parental history. CSF OPN is elevated in amyloid beta(+) positron emission tomography (PET) and tau(+) PET individuals. Elevated CSF OPN is associated with an accelerated rate of conversion to Alzheimer&rsquo;s disease (AD). Elevated CSF OPN is associated with an accelerated rate of cognitive decline on the Alzheimer&rsquo;s Disease Assessment Scale-Cognitive subscale 13, Montreal Cognitive Assessment, Mini-Mental State Examination, and Clinical Dementia Rating Scale Sum of Boxes. OPN mRNA and protein levels are significantly upregulated in the frontal cortex of autopsy-confirmed AD brains.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Quesnel, M. J., Labont\u00e9, A., Picard, C., Bowie, D. C., Zetterberg, H., Blennow, K., Brinkmalm, A., Villeneuve, S., Poirier, J., Alzheimer&rsquo;s Disease Neuroimaging Initiative, &amp; PREVENT\u2010AD Research Group (2024). Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer&rsquo;s disease. Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association, 20(9), 6008\u20136031. https:\/\/doi.org\/10.1002\/alz.14065 Full text [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2984,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2981","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-228x300.jpg",228,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia.jpg",761,1000,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/AlzDementia-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Quesnel, M. J., Labont\u00e9, A., Picard, C., Bowie, D. C., Zetterberg, H., Blennow, K., Brinkmalm, A., Villeneuve, S., Poirier, J., Alzheimer&rsquo;s Disease Neuroimaging Initiative, &amp; PREVENT\u2010AD Research Group (2024). Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer&rsquo;s disease. Alzheimer&rsquo;s &amp; dementia : the journal of the Alzheimer&rsquo;s Association, 20(9), 6008\u20136031. https:\/\/doi.org\/10.1002\/alz.14065 Full text&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=2981"}],"version-history":[{"count":6,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2981\/revisions"}],"predecessor-version":[{"id":3105,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2981\/revisions\/3105"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2984"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=2981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=2981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=2981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}