{"id":2975,"date":"2024-07-01T10:52:12","date_gmt":"2024-07-01T14:52:12","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2975"},"modified":"2025-04-22T10:00:11","modified_gmt":"2025-04-22T14:00:11","slug":"the-neurophysiological-brain-fingerprint-of-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/07\/01\/the-neurophysiological-brain-fingerprint-of-parkinsons-disease\/","title":{"rendered":"The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease. (da Silva Castanheira et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2976\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg\" width=\"572\" height=\"768\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg 572w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine-223x300.jpg 223w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine-9x12.jpg 9w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>da Silva Castanheira, J., Wiesman, A. I., Hansen, J. Y., Misic, B., Baillet, S., PREVENT-AD Research Group, &amp; Quebec Parkinson Network (2024). The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease. <em>EBioMedicine<\/em>, <em>105<\/em>, 105201. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105201<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00236-6\/fulltext\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-www-thelancet-com-journals-ebiom-article-piis-2352-3964-24-00236-6-fulltext-span-style-color-var-ast-global-color-0-class-stk-highlight-the-neurophysiological-brain-fingerprint-of-parkinsons-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(24)00236-6\/fulltext\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease<\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>da Silva Castanheira J, Wiesman A.I, Hansen J.Y, Misic B, Baillet S, PREVENT-AD research group, Quebec Parkinson Network. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>eBioMedicine<\/em>, July 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c93930b\" data-block-id=\"c93930b\"><style>.stk-c93930b .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-c93930b .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>Research in healthy young adults shows that characteristic patterns of brain activity define individual \u201cbrain-fingerprints\u201d that are unique to each person. However, variability in these brain-fingerprints increases in individuals with neurological conditions, challenging the clinical relevance and potential impact of the approach. Our study shows that brain-fingerprints derived from neurophysiological brain activity are associated with pathophysiological and clinical traits of individual patients with Parkinson\u2019s disease (PD). We created brain-fingerprints from task-free brain activity recorded through magnetoencephalography in 79 PD patients and compared them with those from two independent samples of age-matched healthy controls (N = 424 total). We decomposed brain activity into arrhythmic and rhythmic components, defining distinct brain-fingerprints for each type from recording durations of up to 4 min and as short as 30 s. The arrhythmic spectral components of cortical activity in patients with Parkinson\u2019s disease are more variable over short periods, challenging the definition of a reliable brain-fingerprint. However, by isolating the rhythmic components of cortical activity, we derived brain-fingerprints that distinguished between patients and healthy controls with about 90% accuracy. The most prominent cortical features of the resulting Parkinson\u2019s brain-fingerprint are mapped to polyrhythmic activity in unimodal sensorimotor regions. Leveraging these features, we also demonstrate that Parkinson\u2019s symptom laterality can be decoded directly from cortical neurophysiological activity. Furthermore, our study reveals that the cortical topography of the Parkinson\u2019s brain-fingerprint aligns with that of neurotransmitter systems affected by the disease\u2019s pathophysiology. The increased moment-to-moment variability of arrhythmic brain-fingerprints challenges patient differentiation and explains previously published results. We outline patient-specific rhythmic brain signaling features that provide insights into both the neurophysiological signature and symptom laterality of Parkinson\u2019s disease. Thus, the proposed definition of a rhythmic brain-fingerprint of Parkinson\u2019s disease may contribute to novel, refined approaches to patient stratification. Symmetrically, we discuss how rhythmic brain-fingerprints may contribute to the improved identification and testing of therapeutic neurostimulation targets.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : da Silva Castanheira, J., Wiesman, A. I., Hansen, J. Y., Misic, B., Baillet, S., PREVENT-AD Research Group, &amp; Quebec Parkinson Network (2024). The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease. EBioMedicine, 105, 105201. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105201 Full text : Here The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease da Silva Castanheira J, Wiesman A.I, Hansen J.Y, Misic B, Baillet [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2976,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg",572,768,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine-223x300.jpg",223,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg",572,768,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg",572,768,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg",572,768,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine.jpg",572,768,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/ebiomedecine-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : da Silva Castanheira, J., Wiesman, A. I., Hansen, J. Y., Misic, B., Baillet, S., PREVENT-AD Research Group, &amp; Quebec Parkinson Network (2024). The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease. EBioMedicine, 105, 105201. https:\/\/doi.org\/10.1016\/j.ebiom.2024.105201 Full text : Here The neurophysiological brain-fingerprint of Parkinson&rsquo;s disease da Silva Castanheira J, Wiesman A.I, Hansen J.Y, Misic B, Baillet&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=2975"}],"version-history":[{"count":8,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2975\/revisions"}],"predecessor-version":[{"id":3125,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2975\/revisions\/3125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2976"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=2975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=2975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=2975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}