{"id":2957,"date":"2024-06-03T09:53:00","date_gmt":"2024-06-03T13:53:00","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2957"},"modified":"2025-04-22T09:53:58","modified_gmt":"2025-04-22T13:53:58","slug":"neuromodulatory-subcortical-nucleus-integrity-is-associated-with-white-matter-microstructure-tauopathy-and-apoe-status","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/06\/03\/neuromodulatory-subcortical-nucleus-integrity-is-associated-with-white-matter-microstructure-tauopathy-and-apoe-status\/","title":{"rendered":"Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status. (Wearn et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width: 768px){.stk-0bb6bd7 {flex:var(--stk-flex-grow, 1) 1 calc(25% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2959\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg\" width=\"200\" height=\"265\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg 200w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover-9x12.jpg 9w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Wearn, A., Tremblay, S. A., Tardif, C. L., Leppert, I. R., Gauthier, C. J., Baracchini, G., Hughes, C., Hewan, P., Tremblay-Mercier, J., Rosa-Neto, P., Poirier, J., Villeneuve, S., Schmitz, T. W., Turner, G. R., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status. <em>Nature communications<\/em>, <em>15<\/em>(1), 4706. https:\/\/doi.org\/10.1038\/s41467-024-48490-z<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-48490-z\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width: 768px){.stk-36f0c6d {flex:var(--stk-flex-grow, 1) 1 calc(75% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-www-nature-com-articles-s-41467-024-48490-z-span-style-color-var-ast-global-color-0-class-stk-highlight-neuromodulatory-subcortical-nucleus-integrity-is-associated-with-white-matter-microstructure-tauopathy-and-apoe-status-span-a-a-href-https-doi-org-10-1093-braincomms-fcae-031-span-style-color-var-ast-global-color-0-class-stk-highlight-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-48490-z\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status.<\/span><\/a><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcae031\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\"> <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Wearn A, Tremblay S.A, Tardif C.L, Leppert I.R, Gauthier C.J, Baracchini J, Hughes C, Hewan P, Tremblay-Mercier J, Rosa-Neto P, Poirier J, Villeneuve S, Schmitz T.W, Turner G.R, Spreng N, &amp; the PREVENT-AD research group. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Nature Communications<\/em>, June 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-ee86113\" data-block-id=\"ee86113\"><style>.stk-ee86113 .stk-block-text__text{font-size:12px !important;}@media screen and (max-width: 1023px){.stk-ee86113 .stk-block-text__text{font-size:12px !important;}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT: <\/strong><br>The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer\u2019s disease (AD). They project broadly throughout the brain\u2019s white matter. We investigated the relationship between IdC microstructure and whole-brain white matter microstructure to better understand early neuropathological changes in AD. Using multiparametric quantitative magnetic resonance imaging we observed two covariance patterns between IdC and white matter microstructure in 133 cognitively unimpaired older adults (age 67.9\u2009\u00b1\u20095.3 years) with familial risk for AD. IdC integrity related to 1) whole-brain neurite density, and 2) neurite orientation dispersion in white matter tracts known to be affected early in AD. Pattern 2 was associated with CSF concentration of phosphorylated-tau, indicating AD specificity. Apolipoprotein-E4 carriers expressed both patterns more strongly than non-carriers. IdC microstructure variation is reflected in white matter, particularly in AD-affected tracts, highlighting an early mechanism of pathological development.<\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Citation : Wearn, A., Tremblay, S. A., Tardif, C. L., Leppert, I. R., Gauthier, C. J., Baracchini, G., Hughes, C., Hewan, P., Tremblay-Mercier, J., Rosa-Neto, P., Poirier, J., Villeneuve, S., Schmitz, T. W., Turner, G. R., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2959,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover-150x150.jpg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover.jpg",200,265,false],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/12\/Nature_Communications_-_Journal_Cover-9x12.jpg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Wearn, A., Tremblay, S. A., Tardif, C. L., Leppert, I. R., Gauthier, C. J., Baracchini, G., Hughes, C., Hewan, P., Tremblay-Mercier, J., Rosa-Neto, P., Poirier, J., Villeneuve, S., Schmitz, T. W., Turner, G. R., Spreng, R. N., &amp; PREVENT-AD Research Group (2024). Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=2957"}],"version-history":[{"count":9,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2957\/revisions"}],"predecessor-version":[{"id":3121,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2957\/revisions\/3121"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2959"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=2957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=2957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=2957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}