{"id":2048,"date":"2024-03-02T15:04:33","date_gmt":"2024-03-02T20:04:33","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=2048"},"modified":"2024-05-30T10:45:09","modified_gmt":"2024-05-30T14:45:09","slug":"longer-sleep-duration-and-neuroinflammation-in-at-risk-elderly-with-a-parental-history-of-alzheimers-disease-baril-aa-et-al-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/03\/02\/longer-sleep-duration-and-neuroinflammation-in-at-risk-elderly-with-a-parental-history-of-alzheimers-disease-baril-aa-et-al-2024\/","title":{"rendered":"Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer\u2019s disease. (Baril AA. et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width:768px){.stk-0bb6bd7{flex:var(--stk-flex-grow,1) 1 calc(25% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-2774\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-scaled.jpeg\" width=\"1779\" height=\"2560\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-scaled.jpeg 1779w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-208x300.jpeg 208w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-712x1024.jpeg 712w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-768x1105.jpeg 768w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-1067x1536.jpeg 1067w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-1423x2048.jpeg 1423w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-8x12.jpeg 8w\" sizes=\"auto, (max-width: 1779px) 100vw, 1779px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT-AD Research Group (2024). Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer&rsquo;s disease.&nbsp;<em>Sleep<\/em>, zsae081. Advance online publication. https:\/\/doi.org\/10.1093\/sleep\/zsae081<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/academic.oup.com\/sleep\/advance-article\/doi\/10.1093\/sleep\/zsae081\/7634522?login=false\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width:768px){.stk-36f0c6d{flex:var(--stk-flex-grow,1) 1 calc(75% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-academic-oup-com-sleep-advance-article-doi-10-1093-sleep-zsae-081-7634522-login-false-target-blank-rel-noreferrer-noopener-span-style-color-var-ast-global-color-0-class-stk-highlight-longer-sleep-duration-and-neuroinflammation-in-at-risk-elderly-with-a-parental-history-of-alzheimers-disease-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/academic.oup.com\/sleep\/advance-article\/doi\/10.1093\/sleep\/zsae081\/7634522?login=false\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer\u2019s disease. <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>Baril AA, Picard C, Labont\u00e9 A, Sanchez E, Duclos C, Mohammediyan B, Breitner JCS, Villeneuve S, Poirier J; PREVENT-AD Research Group. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\"> <\/span><\/em><br><br>published in <em>Sleep,<\/em> March 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br><strong>Study objectives:&nbsp;<\/strong>While short sleep could promote neurodegeneration, long sleep may be a marker of ongoing neurodegeneration, potentially as a result of neuroinflammation. The objective was to evaluate sleep patterns with age of expected Alzheimer&rsquo;s disease (AD) onset and neuroinflammation.<br><strong>Methods:&nbsp;<\/strong>We tested 203 dementia-free participants (68.5\u00b15.4y\/o, 78M). The PREVENT-AD cohort includes older persons with a parental history of AD whose age was nearing their expected AD onset. We estimated expected years to AD onset by subtracting the participant&rsquo;s age from their parent&rsquo;s at AD dementia onset. We extracted actigraphy sleep variables of interest (times of sleep onset and morning awakening, time in bed, sleep efficiency, sleep duration) and general profiles (sleep fragmentation, phase delay, hypersomnia). CSF inflammatory biomarkers were assessed with OLINK multiplex technology.<br><strong>Results:&nbsp;<\/strong>Proximity to, or exceeding, expected age of onset was associated with a sleep profile suggestive of hypersomnia (longer sleep, later morning awakening time). This hypersomnia sleep profile was associated with higher CSF neuroinflammatory biomarkers (IL-6, MCP-1, global score). Interactions analyses revealed that some of these sleep-neuroinflammation associations were present mostly in those closer\/exceeding the age of expected AD onset, APOE4 carriers, and those with better memory performance.<br><strong>Conclusions:&nbsp;<\/strong>Proximity to, or exceeding, parental AD dementia onset was associated with a longer sleep pattern, which was related to elevated proinflammatory CSF biomarkers. We speculate that longer sleep may serve a compensatory purpose potentially triggered by neuroinflammation as individuals are approaching AD onset. Further studies should investigate whether neuroinflammatory-triggered long sleep duration could mitigate cognitive deficits.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Citation : Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT-AD Research Group (2024). Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer&rsquo;s disease.&nbsp;Sleep, zsae081. Advance online publication. https:\/\/doi.org\/10.1093\/sleep\/zsae081 Full text : Here Longer sleep duration [&hellip;]<\/p>","protected":false},"author":2,"featured_media":2774,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-2048","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-scaled.jpeg",1779,2560,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-150x150.jpeg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-208x300.jpeg",208,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-768x1105.jpeg",768,1105,true],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-712x1024.jpeg",712,1024,true],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-1067x1536.jpeg",1067,1536,true],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-1423x2048.jpeg",1423,2048,true],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/03\/Sleep-March-2024-Cover-8x12.jpeg",8,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"Citation : Baril, A. A., Picard, C., Labont\u00e9, A., Sanchez, E., Duclos, C., Mohammediyan, B., Breitner, J. C. S., Villeneuve, S., Poirier, J., &amp; PREVENT-AD Research Group (2024). Longer sleep duration and neuroinflammation in at-risk elderly with a parental history of Alzheimer&rsquo;s disease.&nbsp;Sleep, zsae081. Advance online publication. https:\/\/doi.org\/10.1093\/sleep\/zsae081 Full text : Here Longer sleep duration&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=2048"}],"version-history":[{"count":3,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2048\/revisions"}],"predecessor-version":[{"id":2775,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/2048\/revisions\/2775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/2774"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=2048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=2048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=2048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}