{"id":1649,"date":"2024-02-01T00:00:44","date_gmt":"2024-02-01T05:00:44","guid":{"rendered":"https:\/\/www.centre-stopad.com\/?p=1649"},"modified":"2024-05-08T17:30:08","modified_gmt":"2024-05-08T21:30:08","slug":"tau-accumulation-and-its-spatial-progression-across-the-alzheimers-disease-spectrum-2024","status":"publish","type":"post","link":"https:\/\/www.centre-stopad.com\/en\/2024\/02\/01\/tau-accumulation-and-its-spatial-progression-across-the-alzheimers-disease-spectrum-2024\/","title":{"rendered":"Tau accumulation and its spatial progression across the Alzheimer\u2019s disease spectrum. (St-Onge F. et al., 2024)"},"content":{"rendered":"<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-f68af85\" data-block-id=\"f68af85\"><style>.stk-f68af85-column{--stk-columns-spacing:12px !important;--stk-column-gap:12px !important}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-f68af85-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0bb6bd7\" data-v=\"4\" data-block-id=\"0bb6bd7\"><style>@media screen and (min-width:768px){.stk-0bb6bd7{flex:1 1 calc(25% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0bb6bd7-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0bb6bd7-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-3a7774a\" data-block-id=\"3a7774a\"><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1952\" src=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-scaled.jpeg\" width=\"1982\" height=\"2560\" srcset=\"https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-scaled.jpeg 1982w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-232x300.jpeg 232w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-793x1024.jpeg 793w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-768x992.jpeg 768w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-1189x1536.jpeg 1189w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-1586x2048.jpeg 1586w, https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-9x12.jpeg 9w\" sizes=\"auto, (max-width: 1982px) 100vw, 1982px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-fc0d2be\" data-block-id=\"fc0d2be\"><style>.stk-fc0d2be .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-fc0d2be .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #abb8c3;\" class=\"stk-highlight\"><strong>Citation : <\/strong><br>St-Onge, F., Chapleau, M., Breitner, J. C. S., Villeneuve, S., &amp; Pichet Binette, A. (2024). Tau accumulation and its spatial progression across the Alzheimer&rsquo;s disease spectrum.&nbsp;<em>Brain communications<\/em>,&nbsp;<em>6<\/em>(1), fcae031. https:\/\/doi.org\/10.1093\/braincomms\/fcae031<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-0055278\" data-block-id=\"0055278\"><style>.stk-0055278 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-0055278 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #0693e3;\" class=\"stk-highlight\">Full text : <\/span><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcae031\" target=\"_blank\" rel=\"noreferrer noopener\">Here<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-36f0c6d\" data-v=\"4\" data-block-id=\"36f0c6d\"><style>@media screen and (min-width:768px){.stk-36f0c6d{flex:1 1 calc(75% - var(--stk-column-gap,0px) * 1 \/ 2 ) !important}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-36f0c6d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-36f0c6d-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-4b1e40a\" id=\"a-href-https-doi-org-10-1093-braincomms-fcae-031-span-style-color-var-ast-global-color-0-class-stk-highlight-tau-accumulation-and-its-spatial-progression-across-the-alzheimers-disease-spectrum-span-a\" data-block-id=\"4b1e40a\"><h2 class=\"stk-block-heading__text\"><a href=\"https:\/\/doi.org\/10.1093\/braincomms\/fcae031\"><span style=\"color: var(--ast-global-color-0);\" class=\"stk-highlight\">Tau accumulation and its spatial progression across the Alzheimer\u2019s disease spectrum. <\/span><\/a><\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-c5ea493\" data-block-id=\"c5ea493\"><p class=\"stk-block-text__text has-text-align-justify\"><strong>St-Onge F, Chapleau M, Breitner JCS, Villeneuve S*, Pichet Binette A*, for the Alzheimer\u2019s Disease Neuroimaging Initiative. <\/strong><em><span style=\"color: #abb8c3;\" class=\"stk-highlight\">*Theses authors contributed equally. <\/span><\/em><br><br>published in <em>Brain Communications<\/em>, February 2024. <\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b6385a4\" data-block-id=\"b6385a4\"><style>.stk-b6385a4 .stk-block-text__text{font-size:12px !important}@media screen and (max-width:1023px){.stk-b6385a4 .stk-block-text__text{font-size:12px !important}}<\/style><p class=\"stk-block-text__text has-text-align-justify\"><strong>ABSTRACT<\/strong> <strong>:<\/strong><br>The accumulation of tau abnormality in sporadic Alzheimer\u2019s disease is believed typically to follow neuropathologically defined Braak staging. Recent&nbsp;<em>in-vivo<\/em>&nbsp;PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer\u2019s disease. We, therefore, sought a better understanding of the spatial distribution of tau in the preclinical and clinical phases of sporadic Alzheimer\u2019s disease and its association with cognitive decline. Longitudinal tau-PET data (1370 scans) from 832 participants (463 cognitively unimpaired, 277 with mild cognitive impairment and 92 with Alzheimer\u2019s disease dementia) were obtained from the Alzheimer\u2019s Disease Neuroimaging Initiative. Among these, we defined thresholds of abnormal tau deposition in 70 brain regions from the Desikan atlas, and for each group of regions characteristic of Braak staging. We summed each scan\u2019s number of regions with abnormal tau deposition to form a spatial extent index. We then examined patterns of tau pathology cross-sectionally and longitudinally and assessed their heterogeneity. Finally, we compared our spatial extent index of tau uptake with a temporal meta-region of interest\u2014a commonly used proxy of tau burden\u2014assessing their association with cognitive scores and clinical progression. More than 80% of amyloid-beta positive participants across diagnostic groups followed typical Braak staging, both cross-sectionally and longitudinally. Within each Braak stage, however, the pattern of abnormality demonstrated significant heterogeneity such that the overlap of abnormal regions across participants averaged less than 50%, particularly in persons with mild cognitive impairment. Accumulation of tau progressed more rapidly among cognitively unimpaired and participants with mild cognitive impairment (1.2 newly abnormal regions per year) compared to participants with Alzheimer\u2019s disease dementia (less than 1 newly abnormal region per year). Comparing the association of tau pathology and cognitive performance our spatial extent index was superior to the temporal meta-region of interest for identifying associations with memory in cognitively unimpaired individuals and explained more variance for measures of executive function in patients with mild cognitive impairments and Alzheimer\u2019s disease dementia. Thus, while participants broadly followed Braak stages, significant individual regional heterogeneity of tau binding was observed at each clinical stage. Progression of the spatial extent of tau pathology appears to be fastest in cognitively unimpaired and persons with mild cognitive impairment. Exploring the spatial distribution of tau deposits throughout the entire brain may uncover further pathological variations and their correlation with cognitive impairments.<br><br><\/p><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>ABSTRACT :<br \/>\nThe accumulation of tau abnormality in sporadic Alzheimer\u2019s disease is believed typically to follow neuropathologically defined Braak staging. Recent\u00a0in-vivo\u00a0PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer\u2019s disease. We, therefore, sought a better understanding of the spatial distribution of tau in the preclinical and clinical phases of sporadic Alzheimer\u2019s disease and its association with cognitive decline. Longitudinal tau-PET data (1370 scans) from 832 participants (463 cognitively unimpaired, 277 with mild cognitive impairment and 92 with Alzheimer\u2019s disease dementia) were obtained from the Alzheimer\u2019s Disease Neuroimaging Initiative. Among these, we defined thresholds of abnormal tau deposition in 70 brain regions from the Desikan atlas, and for each group of regions characteristic of Braak staging. We summed each scan\u2019s number of regions with abnormal tau deposition to form a spatial extent index. We then examined patterns of tau pathology cross-sectionally and longitudinally and assessed their heterogeneity. Finally, we compared our spatial extent index of tau uptake with a temporal meta-region of interest\u2014a commonly used proxy of tau burden\u2014assessing their association with cognitive scores and clinical progression. More than 80% of amyloid-beta positive participants across diagnostic groups followed typical Braak staging, both cross-sectionally and longitudinally. Within each Braak stage, however, the pattern of abnormality demonstrated significant heterogeneity such that the overlap of abnormal regions across participants averaged less than 50%, particularly in persons with mild cognitive impairment. Accumulation of tau progressed more rapidly among cognitively unimpaired and participants with mild cognitive impairment (1.2 newly abnormal regions per year) compared to participants with Alzheimer\u2019s disease dementia (less than 1 newly abnormal region per year). Comparing the association of tau pathology and cognitive performance our spatial extent index was superior to the temporal meta-region of interest for identifying associations with memory in cognitively unimpaired individuals and explained more variance for measures of executive function in patients with mild cognitive impairments and Alzheimer\u2019s disease dementia. Thus, while participants broadly followed Braak stages, significant individual regional heterogeneity of tau binding was observed at each clinical stage. Progression of the spatial extent of tau pathology appears to be fastest in cognitively unimpaired and persons with mild cognitive impairment. Exploring the spatial distribution of tau deposits throughout the entire brain may uncover further pathological variations and their correlation with cognitive impairments.<\/p>","protected":false},"author":2,"featured_media":1952,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[11,9],"tags":[15],"class_list":["post-1649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","category-publication-scientifique","tag-publications-scientifiques"],"uagb_featured_image_src":{"full":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-scaled.jpeg",1982,2560,false],"thumbnail":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-150x150.jpeg",150,150,true],"medium":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-232x300.jpeg",232,300,true],"medium_large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-768x992.jpeg",768,992,true],"large":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-793x1024.jpeg",793,1024,true],"1536x1536":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-1189x1536.jpeg",1189,1536,true],"2048x2048":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-1586x2048.jpeg",1586,2048,true],"trp-custom-language-flag":["https:\/\/www.centre-stopad.com\/wp-content\/uploads\/2024\/02\/braincomms_6_1cover-9x12.jpeg",9,12,true]},"uagb_author_info":{"display_name":"Jennifer Tremblay-Mercier","author_link":"https:\/\/www.centre-stopad.com\/en\/author\/jennifer-tremblay-mercier\/"},"uagb_comment_info":0,"uagb_excerpt":"ABSTRACT : The accumulation of tau abnormality in sporadic Alzheimer\u2019s disease is believed typically to follow neuropathologically defined Braak staging. Recent\u00a0in-vivo\u00a0PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer\u2019s disease. We, therefore, sought a better understanding of the spatial distribution of tau in&hellip;","_links":{"self":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/1649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/comments?post=1649"}],"version-history":[{"count":10,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/1649\/revisions"}],"predecessor-version":[{"id":2002,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/posts\/1649\/revisions\/2002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media\/1952"}],"wp:attachment":[{"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/media?parent=1649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/categories?post=1649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.centre-stopad.com\/en\/wp-json\/wp\/v2\/tags?post=1649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}